ArticleNature communications2020
Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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Who cites it
53 citing papers in PubMed, 69 citations in OpenAlex.
- Clade 2.3.4.4b H5N1 influenza virus and SARS-CoV-2 seroprevalence among owned and feral cats in Philadelphia and surrounding communities.bioRxiv : the preprint server for biology · 2026Article
- Identifying host-specific patterns in viral protein sequences to predict host spillover risk in animal and plant kingdoms.Scientific reports · 2026Article
- Assessment of pre and postinfection immunity to the hemagglutinin proteins of Influenza A(H1N1)pdm09 and Influenza A(H3N2) in India: a retrospective longitudinal study.Virology journal · 2026Article
- CAPYBARA: A generalizable framework for predicting serological measurements across human cohorts.PLoS computational biology · 2026Article
- The Decline in Influenza Antibody Titers and Modifiers of Vaccine Immunity from over Ten Years of Serological Data.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers.NPJ vaccines · 2025Article
- Breadth of influenza A antibody cross-reactivity varies by virus isolation interval and subtype.Nature microbiology · 2025Article
- Structural mapping of polyclonal IgG responses to HA after influenza virus vaccination or infection.mBio · 2025Article
- Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model.Journal of virology · 2025Article
- Measures of Population Immunity Can Predict the Dominant Clade of Influenza A (H3N2) in the 2017-2018 Season and Reveal Age-Associated Differences in Susceptibility and Antibody-Binding Specificity.Influenza and other respiratory viruses · 2024Article
- A guide to adaptive immune memory.Nature reviews. Immunology · 2024Review
- Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course.PLoS biology · 2024Article
- Vaccination against rapidly evolving pathogens and the entanglements of memory.Nature immunology · 2024Review
- Measures of population immunity can predict the dominant clade of influenza A (H3N2) in the 2017-2018 season and reveal age-associated differences in susceptibility and antibody-binding specificity.medRxiv : the preprint server for health sciences · 2024Article
- Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.Cell host & microbe · 2024Article
- Commuting-driven competition between transmission chains shapes seasonal influenza virus epidemics in the United States.medRxiv : the preprint server for health sciences · 2024Article
- Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin.Nature microbiology · 2024Article
- Structural Mapping of Polyclonal IgG Responses to HA After Influenza Virus Vaccination or Infection.bioRxiv : the preprint server for biology · 2024Article
- A speed limit on serial strain replacement from original antigenic sin.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Influenza virus exposures in childhood can establish long-lived memory B cell responses that can be recalled later in life. Here, we complete a large serological survey to elucidate the specificity of antibodies against contemporary H3N2 viruses in differently aged individuals who were likely primed with different H3N2 strains in childhood. We find that most humans who were first infected in childhood with H3N2 viral strains from the 1960s and 1970s possess non-neutralizing antibodies against contemporary 3c2.A H3N2 viruses. We find that 3c2.A H3N2 virus infections boost non-neutralizing H3N2 antibodies in middle-aged individuals, potentially leaving many of them in a perpetual state of 3c2.A H3N2 viral susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.