Evidence map›Paper›PMID 32917852›Full record

ArticleCell death & disease2020

Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.

Wencheng Dai, Xiaoxia Jin, Liang Han, Haijing Huang, Zhenhua Ji, Xinjiang Xu, Mingming Tang, Bin Jiang, Weixian Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  9. The role of exosomal long non-coding RNAs in head, neck and thyroid cancers.Medical oncology (Northwood, London, England) · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wencheng DaiDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China.
Xiaoxia JinDepartment of Pathology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China.
Liang HanDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China.
Haijing HuangLaboratory of Nantong Third People's Hospital, No.60 Youth Middle Road, Chongchuan District, 226001, Nantong, Jiangsu, China.
Zhenhua JiDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China.
Xinjiang XuDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China.
Mingming TangDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China.
Bin JiangDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China. jiangzou9951@163.com.
Weixian ChenDepartment of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, No.30 North Tongyang Road, Pingchao, 226361, Nantong, Jiangsu, China. xian285417307396@163.com.
Nantong Tumor Hospital · CNNantong University · CNSecond People's Hospital of NanTong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomal long non-coding RNAs (lncRNAs) are crucial factors that mediate the extracellular communication in tumor microenvironment. DOCK9 antisense RNA2 (DOCK9-AS2) is an exosomal lncRNA which has not been investigated in papillary thyroid carcinoma (PTC). Based on the result of differentially expressed lncRNAs in PTC via bioinformatics databases, we discovered that DOCK9-AS2 was upregulated in PTC, and presented elevation in plasma exosomes of PTC patients. Functionally, DOCK9-AS2 knockdown reduced proliferation, migration, invasion, epithelial-to-mesenchymal (EMT) and stemness in PTC cells. PTC-CSCs transmitted exosomal DOCK9-AS2 to improve stemness of PTC cells. Mechanistically, DOCK9-AS2 interacted with SP1 to induce catenin beta 1 (CTNNB1) transcription and sponged microRNA-1972 (miR-1972) to upregulate CTNNB1, thereby activating Wnt/β-catenin pathway in PTC cells. In conclusion, PTC-CSCs-derived exosomal lncRNA DOCK9-AS2 activated Wnt/β-catenin pathway to aggravate PTC progression, indicating that DOCK9-AS2 was a potential target for therapies in PTC.

Indexed as

Animalsbeta CateninCell MovementCell ProliferationExosomesGuanine Nucleotide Exchange FactorsHumansMaleMiceMice, NudeNeoplasm InvasivenessNeoplastic Stem CellsRNA, Long NoncodingThyroid Cancer, PapillaryTransfectionbeta CateninGuanine Nucleotide Exchange FactorsRNA, Long Noncodingzizimin1 protein, mouse

Identifiers

PMID32917852
PMCPMC7486896
OpenAlexW3086820975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.