ArticleProceedings of the National Academy of Sciences of the United States of America2020
Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.Biomedicines · 2026Review
- Dynamic recovery of piriform cortex function and its impact on cognitive processing speed following mild COVID-19.BMC neurology · 2026Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Causal disconnectomics of motion perception networks: insights from transcranial magnetic stimulation-induced BOLD responses.The Journal of physiology · 2026Article
- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
- Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Early-life adversities compromise behavioral development in male and female mice heterozygous for CNTNAP2.Neurobiology of stress · 2025Article
- Brain-wide microstrokes affect the stability of memory circuits in the hippocampus.Nature communications · 2025Article
- Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits.bioRxiv : the preprint server for biology · 2025Article
- Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes.Frontiers in human neuroscience · 2025Article
- Homeostatic plasticity in patients with disorders of consciousness detected by combined stimulation: a study protocol.Frontiers in neurology · 2025Article
- Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.PLoS computational biology · 2025Article
- Dimensionality reduction of quantitative EEG and clinical profiles uncover associations with monogenic neurodevelopmental phenotypes in SNAREopathies.Frontiers in neuroscience · 2025Article
- Neuroplasticity in autism spectrum disorder: a systematic review.Dementia & neuropsychologia · 2025Review
- Homeostatic synaptic normalization optimizes learning in network models of neural population codes.eLife · 2024Article
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4 authors.
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Abstract
Homeostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity. Although it is commonly assumed that homeostasis modulates synaptic strength, membrane excitability, and firing rates, its role at the neural circuit and network level is unknown. Here, we identify changes in higher-order network properties of freely behaving rodents during prolonged visual deprivation. Strikingly, our data reveal that functional pairwise correlations and their structure are subject to homeostatic regulation. Using a computational model, we demonstrate that the interplay of different plasticity and homeostatic mechanisms can capture the initial drop and delayed recovery of firing rates and correlations observed experimentally. Moreover, our model indicates that synaptic scaling is crucial for the recovery of correlations and network structure, while intrinsic plasticity is essential for the rebound of firing rates, suggesting that synaptic scaling and intrinsic plasticity can serve distinct functions in homeostatically regulating network dynamics.
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