Evidence map›Paper›PMID 32917807›Full record

ArticleNeurology2020

Familial aggregation of status epilepticus in generalized and focal epilepsies.

Judith L Z Weisenberg, Robert T Fitzgerald, John N Constantino, Melodie R Winawer, Liu Lin Thio, EPGP Investigators

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00552045 (Epilepsy Phenome/Genome Project), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00552045 completednot on this map

Epilepsy Phenome/Genome Project: A Phenotype/Genotype Analysis of Epilepsy

TypeobservationalSponsorUniversity of California, San FranciscoRan2007 to 2018Enrolled4,150ConditionsEpilepsy, Localization-related Epilepsy, Infantile Spasms, Lennox-Gastaut Syndrome
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Judith L Z WeisenbergFrom the Division of Pediatric and Developmental Neurology, Department of Neurology (J.L.Z.W., L.L.T.) and Department of Psychiatry (R.T.F., J.N.C.), Washington University, St. Louis, MO; and Department of Neurology (M.R.W.), College of Physicians and Surgeons, Columbia University, New York, NY. weisenberj@wustl.edu.
Robert T FitzgeraldFrom the Division of Pediatric and Developmental Neurology, Department of Neurology (J.L.Z.W., L.L.T.) and Department of Psychiatry (R.T.F., J.N.C.), Washington University, St. Louis, MO; and Department of Neurology (M.R.W.), College of Physicians and Surgeons, Columbia University, New York, NY.
John N ConstantinoFrom the Division of Pediatric and Developmental Neurology, Department of Neurology (J.L.Z.W., L.L.T.) and Department of Psychiatry (R.T.F., J.N.C.), Washington University, St. Louis, MO; and Department of Neurology (M.R.W.), College of Physicians and Surgeons, Columbia University, New York, NY.
Melodie R WinawerFrom the Division of Pediatric and Developmental Neurology, Department of Neurology (J.L.Z.W., L.L.T.) and Department of Psychiatry (R.T.F., J.N.C.), Washington University, St. Louis, MO; and Department of Neurology (M.R.W.), College of Physicians and Surgeons, Columbia University, New York, NY.
Liu Lin ThioFrom the Division of Pediatric and Developmental Neurology, Department of Neurology (J.L.Z.W., L.L.T.) and Department of Psychiatry (R.T.F., J.N.C.), Washington University, St. Louis, MO; and Department of Neurology (M.R.W.), College of Physicians and Surgeons, Columbia University, New York, NY.
EPGP Investigators
Columbia University · US

Funding

The Epilepsy Phenome/ Genome Project (EPGP)U01NS053998 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWENSTEIN, DANIEL H · 2007 to 2013
$26.4M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
NICHD NIH HHS P50 HD103525NINDS NIH HHS U01 NS053998
6 · The paper itself

Abstract

objectiveTo determine whether familial aggregation of status epilepticus (SE) occurs in a large cohort of familial common epilepsies.

methodsWe used the Epilepsy Phenome/Genome Project dataset, which consisted of 2,197 participants in 1,043 family units with ≥2 members having a common generalized or nonacquired focal epilepsy (NAFE). We identified participants with a history of traditionally defined SE (TSE) (seizures ≥30 minutes) and operationally defined SE (OSE) (seizures ≥10 minutes) by chart review. We assessed familial aggregation of TSE and OSE using χ

resultsOne hundred fifty-five (7%) participants in 1,043 families had ≥1 episodes of TSE. Two hundred fifty (11%) had ≥1 episodes of OSE. In a χ

conclusionsTSE and OSE showed robust familial aggregation in a cohort of familial epilepsy independently of epilepsy severity or class, suggesting that genetic factors contribute to SE independently of the genetic cause of these epilepsies. CLINICALTRIALSGOV IDENTIFIER: NCT00552045.

Indexed as

AdolescentAdultChildDatabases, GeneticEpilepsies, PartialEpilepsy, GeneralizedFamily HealthFemaleHumansMaleStatus EpilepticusTime FactorsYoung Adult

Identifiers

PMID32917807
PMCPMC7713751
OpenAlexW3084621147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.