Evidence map›Paper›PMID 32917794›Full record

ArticleeNeuro

Variable Interhemispheric Asymmetry in Layer V of the Supplementary Motor Area following Cervical Hemisection in Adult Macaque Monkeys.

A Contestabile, R Colangiulo, M Lucchini, E M Rouiller, E Schmidlin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A ContestabileDepartment of Basic Neuroscience, University of Geneva, Genève CH-1205, Switzerland.ORCID 0000-0001-6528-1403
R ColangiuloDepartment of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition, University of Fribourg, Fribourg CH-1700, Switzerland.
M LucchiniDepartment of Basic Neuroscience, University of Geneva, Genève CH-1205, Switzerland.
E M RouillerDepartment of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition, University of Fribourg, Fribourg CH-1700, Switzerland.
E SchmidlinDepartment of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition, University of Fribourg, Fribourg CH-1700, Switzerland eric.schmidlin@unifr.ch.ORCID 0000-0001-8638-2369
University of Fribourg · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motor cortical areas from both hemispheres play a role during functional recovery after a unilateral spinal cord injury (SCI). However, little is known about the morphologic and phenotypical differences that a SCI could trigger in corticospinal (CS) neurons of the ipsilesional and contralesional hemisphere. Using an SMI-32 antibody which specifically labeled pyramidal neurons in cortical Layers V, we investigated the impact of a unilateral cervical cord lesion on the rostral part (F6) and caudal part (F3) of the supplementary motor area (SMA) in both hemispheres of eight adult macaque monkeys compared with four intact control monkeys. We observed in F3 (but not in F6) interindividual variable and adaptive interhemispheric asymmetries of SMI-32-positive Layer V neuronal density and dendritic arborization, which are strongly correlated with the extent of the SCI as well as the duration of functional recovery, but not with the extent (percentage) of functional recovery.

Indexed as

Motor CortexSpinal Cord InjuriesAnimalsHaplorhiniMacacaRecovery of Functioncorticospinal projectionsinterhemispheric asymmetrynon-human primatepyramidal neuronsspinal cord injurysupplementary motor area

Identifiers

PMID32917794
PMCPMC7548435
OpenAlexW3086284532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.