ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Mice Preferentially Use Increases in Cerebral Cortex Spiking to Detect Changes in Visual Stimuli.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Visual uncertainty and task demands shape active sensing strategies in mice.Current biology : CB · 2026Article
- Visual uncertainty and task demands shape active sensing strategies in mice.bioRxiv : the preprint server for biology · 2026Article
- Map of spiking activity underlying change detection in the mouse visual system.bioRxiv : the preprint server for biology · 2025Article
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
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- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.Current biology : CB · 2024Article
- Population coding of time-varying sounds in the nonlemniscal inferior colliculus.Journal of neurophysiology · 2024Article
- All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse.Cell reports · 2023Article
- Population coding of time-varying sounds in the non-lemniscal Inferior Colliculus.bioRxiv : the preprint server for biology · 2023Article
- Increments in visual motion coherence are more readily detected than decrements.Journal of vision · 2023Article
- Normalization in mouse primary visual cortex.PloS one · 2023Article
- Breaking Down a Rhythm: Dissecting the Mechanisms Underlying Task-Related Neural Oscillations.Frontiers in neural circuits · 2022Review
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Authors and funding
6 authors.
Funding
Abstract
Whenever the retinal image changes, some neurons in visual cortex increase their rate of firing whereas others decrease their rate of firing. Linking specific sets of neuronal responses with perception and behavior is essential for understanding mechanisms of neural circuit computation. We trained mice of both sexes to perform visual detection tasks and used optogenetic perturbations to increase or decrease neuronal spiking primary visual cortex (V1). Perceptual reports were always enhanced by increments in V1 spike counts and impaired by decrements, even when increments and decrements in spiking were generated in the same neuronal populations. Moreover, detecting changes in cortical activity depended on spike count integration rather than instantaneous changes in spiking. Recurrent neural networks trained in the task similarly relied on increments in neuronal activity when activity has costs. This work clarifies neuronal decoding strategies used by cerebral cortex to translate cortical spiking into percepts that can be used to guide behavior.
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