ArticleDiabetes2020
Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Genome-wide association study provides novel insight into the genetic architecture of severe obesity.PLoS genetics · 2025Pooled it
- Classification of Congenital Leptin Deficiency.The Journal of clinical endocrinology and metabolism · 2024Pooled it
- Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study.BMC oral health · 2023Pooled it
- The Impact of Lifestyle, Diet and Physical Activity on Epigenetic Changes in the Offspring-A Systematic Review.Nutrients · 2021Pooled it
- Circulating adipokines level and the risk of neurodegenerative diseases: a two‑sample mendelian randomization study and proteomic analysis.BMC neurology · 2026Article
- Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults.Frontiers in medicine · 2026Article
- Obesity in young adults: The differentiated impact of LEP, LEPR, and FTO gene variants.Genetics and molecular biology · 2026Article
- Nutrition meets nephrology in head and neck cancer: the predictive impact of body composition on the onset of acute kidney disease.Frontiers in oncology · 2026Article
- Investigating the contribution of circulating inflammatory cytokines on the link between obesity and COVID-19.Adipocyte · 2025Article
- Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders.Cell genomics · 2025Review
- Article
- Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis.Frontiers in endocrinology · 2025Article
- Beyond BMI: A Mendelian Randomization Study of the Causal Effects and Mediating Pathways of Regional Adipose Tissue Depots on Polycystic Ovary Syndrome.International journal of women's health · 2025Article
- A Mendelian randomization study on causal relationship between metabolic factors and abnormal spermatozoa.Translational andrology and urology · 2024Article
- 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.medRxiv : the preprint server for health sciences · 2024Article
- The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk.EBioMedicine · 2024Article
- Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa.Scientific reports · 2024Article
- Mendelian randomization analyses reveal no genetic causal effects of major adipokines on systemic lupus erythematosus.PloS one · 2024Article
- Mediators between body mass index and atrial fibrillation: a Mendelian randomization study.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
116 authors at 20 institutions in 12 countries.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K. h.yaghootkar@exeter.ac.uk tuomas.kilpelainen@sund.ku.dk.ORCID 0000-0001-9672-9477
Yiying ZhangDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY.
Cassandra N SpracklenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Tugce KaraderiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Lam Opal HuangNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jonathan BradfieldCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.
Claudia SchurmannThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Rebecca S FineDepartment of Genetics, Harvard Medical School, Boston, MA.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Zoltan KutalikGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.
Laura B L WittemansWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Sophia MetzNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sara M WillemsMRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Shuai WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Sophie MolnosGerman Center for Diabetes Research, München-Neuherberg, Germany.
América A Sandoval-ZárateInstitute for Molecular Medicine Finland, Helsinki, Finland.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD.
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado-Denver, Denver, CO.
Jeffrey HaesserPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
Cristina VenturiniDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Tim KacprowskiDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Carol A WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.
Najaf AminDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Linda BroerDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Neil RobertsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Kristin L YoungDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Matthew AllisonDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA.
Paul L AuerJoseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI.
Matthias BlüherMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Judith B BorjaOffice of Population Studies Foundation, Inc., Cebu City, Philippines.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Germán D CarrasquillaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Paraskevi ChristofidouDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.
Ayse DemirkanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Claudia A DoegeDepartment of Pathology and Cell Biology, Columbia University, New York, NY.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Kaiying GuoDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY.
Hakon HakonarsonCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.
Jaeyoung HongDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Rebecca JacksonDivision of Endocrinology, Diabetes, and Metabolism, Ohio State University, Columbus, OH.
Hermina JakupovićNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pekka JousilahtiDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Anne E JusticeCenter for Biomedical and Translational Informatics, Geisinger, Danville, PA.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Jorge R KizerCardiology Section, San Francisco Veterans Affairs Health Care System, University of California San Francisco, San Francisco, CA.
Jennifer KriebelGerman Center for Diabetes Research, München-Neuherberg, Germany.
Charles A LeDucDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY.
Jin LiDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
David A MackeyCentre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, West Australia, Australia.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.
Satu MännistöDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Jayne F Martin CarliDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY.
Carolina Medina-GomezDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Matthias NauckDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Ivana ProkicDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Craig E PennellDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Arund D PradhanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Robert A ScottMRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
Tea SkaabyCenter for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Alexander TeumerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Andre G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Ying WuDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Mark WalkerInstitute of Cellular Medicine (Diabetes), Newcastle University, Newcastle upon Tyne, U.K.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Peter KovacsMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.
Stephen LyeLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Erik IngelssonDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, WA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Linda S AdairCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Alexander P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.
Samuli RipattiBroad Institute of MIT and Harvard, Cambridge, MA.
Harald GrallertGerman Center for Diabetes Research, München-Neuherberg, Germany.
James B MeigsDivision of General Internal Medicine, Massachusetts General Hospital, Boston, MA.
Veikko SalomaaDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ko Willems van DijkDivision of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
Struan F A GrantCenter for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.
Karen L MohlkeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Rudolph L LeibelDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark h.yaghootkar@exeter.ac.uk tuomas.kilpelainen@sund.ku.dk.ORCID 0000-0002-8349-3028
University of Copenhagen · DKErasmus MC · NLUniversity of North Carolina at Chapel Hill · USColumbia University · USMRC Epidemiology Unit · GBUCLA Medical Center · USBoston University · USBroad Institute · USCentre for Human Genetics · GBHelmholtz Zentrum München · DEKing's College - North Carolina · USLeiden University Medical Center · NLUniversitätsmedizin Greifswald · DEBrigham and Women's Hospital · USChildren's Hospital of Philadelphia · USFinnish Institute for Health and Welfare · FITampere University · FIFred Hutch Cancer Center · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MSemiparametric Analysis of Big Censored DataR01HL149683 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2020 to 2023
$1.9MComputational methods to advance from genetic association to biological insightF31HG009850 · NHGRI · HARVARD MEDICAL SCHOOL · PI FINE, REBECCA · 2017 to 2019
$85kMedical Research Council MC_UU_00006/1Medical Research Council MC_UU_12015/1Medical Research Council MR/T002239/1NHGRI NIH HHS F31 HG009850NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL149683NHLBI NIH HHS U01 HL130114NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK093757
Abstract
Leptin influences food intake by informing the brain about the status of body fat stores. Rare
Indexed as
AdiposityGene Expression Regulation, DevelopmentalGenetic VariationGenotypeHumansLeptinModels, MolecularProtein ConformationRacial GroupsLeptin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.