Evidence map›Paper›PMID 32917762›Full record

ArticleBiology open2020

Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development.

Daniel Chu, An Nguyen, Spenser S Smith, Zuzana Vavrušová, Richard A Schneider

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Gene regulatory co-option drives birdsong neural circuit specialization.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Promoters in Pichia pastoris: A Toolbox for Fine-Tuned Gene Expression.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel ChuDepartment of Orthopaedic Surgery, University of California at San Francisco, 513 Parnassus Avenue, S-1164, San Francisco, CA 94143-0514, USA.
An NguyenDepartment of Orthopaedic Surgery, University of California at San Francisco, 513 Parnassus Avenue, S-1164, San Francisco, CA 94143-0514, USA.
Spenser S SmithDepartment of Orthopaedic Surgery, University of California at San Francisco, 513 Parnassus Avenue, S-1164, San Francisco, CA 94143-0514, USA.
Zuzana VavrušováDepartment of Orthopaedic Surgery, University of California at San Francisco, 513 Parnassus Avenue, S-1164, San Francisco, CA 94143-0514, USA.
Richard A SchneiderDepartment of Orthopaedic Surgery, University of California at San Francisco, 513 Parnassus Avenue, S-1164, San Francisco, CA 94143-0514, USA rich.schneider@ucsf.edu.ORCID 0000-0002-2626-3111
University of California, San Francisco · US

Funding

TEMPORAL REGULATION OF CRANIAL SKELETOGENESISR01DE016402 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RICHARD A SCHNEIDER · 2004 to 2026
$8.2M
Mechanisms of Secondary Cartilage Induction and Maintenance in the JawR01DE025668 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHNEIDER, RICHARD A · 2016 to 2020
$2.0M
Macro Confocal Microscope System for Large-Scale Imaging in Basic and Translational BiologyS10OD021664 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHNEIDER, RICHARD A · 2016 to 2016
$377k
Mesenchyme-Dependent Epithelial Signals That Promote Osteogenesis In the JawF30DE027616 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NGUYEN, AN NHAT DUY · 2017 to 2022
$280k
The Role of TGF-Beta Signaling in Neural Crest-Mediated Jaw Bone RemodelingF32DE027283 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SMITH, SPENSER SCOTT · 2018 to 2020
$194k
NIDCR NIH HHS F30 DE027616NIDCR NIH HHS F32 DE027283NIDCR NIH HHS R01 DE016402NIDCR NIH HHS R01 DE025668NIH HHS S10 OD021664Wellcome Trust
6 · The paper itself

Abstract

Precisely altering gene expression is critical for understanding molecular processes of embryogenesis. Although some tools exist for transgene misexpression in developing chick embryos, we have refined and advanced them by simplifying and optimizing constructs for spatiotemporal control. To maintain expression over the entire course of embryonic development we use an enhanced

Indexed as

Gene Expression Regulation, DevelopmentalGenetic VectorsPromoter Regions, GeneticAnimalsCells, CulturedCloning, MolecularDNA Transposable ElementsEmbryonic DevelopmentEmbryo, NonmammalianGene OrderGenes, ReporterGreen Fluorescent ProteinsPlasmidsDNA Transposable ElementsGreen Fluorescent ProteinsAvian embryosGene expressionPiggyBac transposonTet-inducible

Identifiers

PMID32917762
PMCPMC7561481
OpenAlexW3086370222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.