ArticleScience advances2020
The optoretinogram reveals the primary steps of phototransduction in the living human eye.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 164 citations in OpenAlex.
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Impaired Photoreceptor Function in Age-Related Macular Degeneration.Ophthalmology science · 2026Article
- Subretinal Aspects of the Optoretinographic Response.Investigative ophthalmology & visual science · 2026Article
- Synaptic high-frequency jumping synchronises vision to high-speed behaviour.Nature communications · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Dark adaptation of cone photoreceptor responses is revealed by optoretinography.bioRxiv : the preprint server for biology · 2026Article
- Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.bioRxiv : the preprint server for biology · 2026Article
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography.Translational vision science & technology · 2026Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation.Biomedical optics express · 2026Article
- Optoretinography reveals rapid rod photoreceptor movement upon rhodopsin activation.Light, science & applications · 2026Article
- Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration.Investigative ophthalmology & visual science · 2026Article
- Structural analysis of cone photoreceptors in AO-OCT enables S-cone identification by a support vector machine classifier.Biomedical optics express · 2026Article
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Interferometric imaging of the reversible rhodopsin dynamics in the living rat eye.Nature communications · 2025Article
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
- Integrated fixation and stimulus channel for adaptive optics ophthalmoscopy.Biomedical optics express · 2025Article
- Local variations in L/M ratio influence the detection and color naming of small spots.Journal of vision · 2025Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Photoreceptors initiate vision by converting photons to electrical activity. The onset of the phototransduction cascade is marked by the isomerization of photopigments upon light capture. We revealed that the onset of phototransduction is accompanied by a rapid (<5 ms), nanometer-scale electromechanical deformation in individual human cone photoreceptors. Characterizing this biophysical phenomenon associated with phototransduction in vivo was enabled by high-speed phase-resolved optical coherence tomography in a line-field configuration that allowed sufficient spatiotemporal resolution to visualize the nanometer/millisecond-scale light-induced shape change in photoreceptors. The deformation was explained as the optical manifestation of electrical activity, caused due to rapid charge displacement following isomerization, resulting in changes of electrical potential and surface tension within the photoreceptor disc membranes. These all-optical recordings of light-induced activity in the human retina constitute an optoretinogram and hold remarkable potential to reveal the biophysical correlates of neural activity in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.