ArticleScience advances2020
Hedgehog signaling controls segmentation dynamics and diversity via
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Conserved and diverged embryonic expression patterns of panarthropod NK-Cluster genes and new evidence for CRE-shuffling.BMC ecology and evolution · 2026Article
- Assessing the Impact of Whole Genome Duplication on Gene Expression and Regulation During Arachnid Development.Genome biology and evolution · 2025Article
- Assessing the role of key genes involved in the reproductive success of the honey bee parasite Varroa destructor.BMC genomics · 2025Article
- Genome-wide quantitative dissection of an arthropod segmented body plan at single-cell resolution.Communications biology · 2025Article
- Hedgehog Signaling during Gut Formation in the Freshwater Leech, Helobdella austinensis.Cells, tissues, organs · 2025Article
- A taxon-restricted duplicate of Iroquois3 is required for patterning the spider waist.PLoS biology · 2024Article
- An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis.EvoDevo · 2024Article
- Evolution of the Spider Homeobox Gene Repertoire by Tandem and Whole Genome Duplication.Molecular biology and evolution · 2023Article
- Extraembryonic tissue in chelicerates: a review and outlook.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Article
- Eggs to long-legs: embryonic staging of the harvestman Phalangium opilio (Opiliones), an emerging model arachnid.Frontiers in zoology · 2022Article
- Virtual spherical-shaped multicellular platform for simulating the morphogenetic processes of spider-like body axis formation.Frontiers in cell and developmental biology · 2022Article
- Reconstruction of the Global Polarity of an Early Spider Embryo by Single-Cell and Single-Nucleus Transcriptome Analysis.Frontiers in cell and developmental biology · 2022Article
- The Evolution of Sox Gene Repertoires and Regulation of Segmentation in Arachnids.Molecular biology and evolution · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hedgehog (Hh) signaling plays fundamental roles in animal body patterning. Understanding its mechanistic complexity requires simple tractable systems that can be used for these studies. In the early spider embryo, Hh signaling mediates the formation of overall anterior-posterior polarity, yet it remains unclear what mechanisms link the initial Hh signaling activity with body axis segmentation, in which distinct periodic stripe-forming dynamics occur depending on the body region. We performed genome-wide searches for genes that transcriptionally respond to altered states of Hh signaling. Characterization of genes negatively regulated by Hh signaling suggested that
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.