Evidence map›Paper›PMID 32917671›Full record

ArticleBritish journal of sports medicine2021

Prospective study of the association between sport-related concussion and brain morphometry (3T-MRI) in collegiate athletes: study from the NCAA-DoD CARE Consortium.

Samuel A Bobholz, Benjamin L Brett, Lezlie Y España, Daniel L Huber, Andrew R Mayer, Jaroslaw Harezlak, Steven P Broglio, Thomas McAllister, Michael A McCrea, Timothy B Meier and 1 more

Open access · greenAbstract read
In one paragraph

Article in British journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Samuel A BobholzNeurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Benjamin L BrettNeurosurgery and Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID http://orcid.org/0000-0003-2849-4658
Lezlie Y EspañaNeurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID http://orcid.org/0000-0002-6466-4653
Daniel L HuberNeurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Andrew R MayerNeurology and Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Jaroslaw HarezlakEpidemiology and Biostatistics, Indiana University, Bloomington, Indiana, USA.
Steven P BroglioMichigan Concussion Center, University of Michigan, Ann Arbor, Michigan, USA.
Thomas McAllisterPsychiatry, Indiana University School of Medicine, Bloomington, Indiana, USA.
Michael A McCreaNeurosurgery and Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Timothy B MeierNeurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA tmeier@mcw.edu.
CARE Consortium Investigators
Medical College of Wisconsin · USIndiana University Bloomington · USMind Research Network · USUniversity of Michigan · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
The role of neuroactive kynurenine metabolites in the chronic sequelae of concussion and contact sport exposureR01NS102225 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI MEIER, TIMOTHY B. · 2018 to 2022
$1.8M
Inflammation and Kynurenine Metabolites in the Acute Sequelae of ConcussionR21NS099789 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI MEIER, TIMOTHY B. · 2017 to 2018
$443k
NCATS NIH HHS UL1 TR001436NINDS NIH HHS L30 NS113158NINDS NIH HHS R01 NS102225NINDS NIH HHS R21 NS099789
6 · The paper itself

Abstract

objectivesTo determine the acute and early long-term associations of sport-related concussion (SRC) and subcortical and cortical structures in collegiate contact sport athletes.

methodsAthletes with a recent SRC (n=99) and matched contact (n=91) and non-contact sport controls (n=95) completed up to four neuroimaging sessions from 24 to 48 hours to 6 months postinjury. Subcortical volumes (amygdala, hippocampus, thalamus and dorsal striatum) and vertex-wise measurements of cortical thickness/volume were computed using FreeSurfer. Linear mixed-effects models examined the acute and longitudinal associations between concussion and structural metrics, controlling for intracranial volume (or mean thickness) and demographic variables (including prior concussions and sport exposure).

resultsThere were significant group-dependent changes in amygdala volumes across visits (p=0.041); this effect was driven by a trend for increased amygdala volume at 6 months relative to subacute visits in contact controls, with no differences in athletes with SRC. No differences were observed in any cortical metric (ie, thickness or volume) for primary or secondary analyses.

conclusionA single SRC had minimal associations with grey matter structure across a 6-month time frame.

Indexed as

AdolescentAdultAthletic InjuriesBrain ConcussionFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleOrgan SizeProspective StudiesUniversitiesYoung AdultconcussionMRIsport

Identifiers

PMID32917671
PMCPMC7855484
OpenAlexW3086076162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.