Evidence map›Paper›PMID 32917668›Full record

ArticleDevelopment (Cambridge, England)2020

GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells.

Maggie S Matern, Beatrice Milon, Erika L Lipford, Mark McMurray, Yoko Ogawa, Andrew Tkaczuk, Yang Song, Ran Elkon, Ronna Hertzano

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Reprogramming withPNAS nexus · 2024
    Article
  5. Article
  6. Hair Cell Regeneration: From Animals to Humans.Clinical and experimental otorhinolaryngology · 2024
    Review
  7. Expression ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. The Genomics of Auditory Function and Disease.Annual review of genomics and human genetics · 2022
    Review
  18. Three distinctProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maggie S MaternDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Beatrice MilonDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Erika L LipfordDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mark McMurrayDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yoko OgawaDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Andrew TkaczukDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ran ElkonDepartment of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0003-3440-1286
Ronna HertzanoDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA rhertzano@som.umaryland.edu.ORCID 0000-0002-8093-6567
University of Maryland, Baltimore · USTel Aviv University · IL

Funding

AUTOSOMAL DOMINANT NONSYNDROMIC HEARING LOSSR01DC003544 · NIDCD · UNIVERSITY OF IOWA · PI SMITH, RICHARD J.H. · 1998 to 2017
$7.8M
COMPARATIVE AND EVOLUTIONARY BIOLOGY OF HEARINGT32DC000046 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI Catherine Emily Carr, Matthew J. Goupell · 1994 to 2026
$7.5M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentU01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI AHMED, ZUBAIR M. · 2023 to 2025
$1.6M
A Zeiss Duo Confocal Microscope for Shared Imaging FacilityS10RR024548 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2008 to 2008
$500k
Advanced components for an existing spinning disk confocal in an established core imaging facilityS10OD026698 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2019 to 2019
$274k
To be or not to be_GFI1 as a critical factor in hair cell fate and survivalF31DC016218 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI MATERN, MAGGIE S. · 2017 to 2018
$60k
NIDCD NIH HHS F31 DC016218NIDCD NIH HHS R01 DC003544NIDCD NIH HHS R01 DC013817NIDCD NIH HHS T32 DC000046NIDCD NIH HHS U01 DC013817NIH HHS S10 OD026698
6 · The paper itself

Abstract

Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional cascades in the inner ear remain largely unknown. Here, we have used

Indexed as

Gene Expression RegulationAnimalsBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsHair Cells, Auditory, InnerMiceMice, TransgenicRepressor ProteinsTranscription Factor Brn-3ATranscription FactorsAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsGfi1 protein, mouseInsm1 protein, mouseNeurod1 protein, mousePou4f1 protein, mouseRepressor ProteinsTranscription Factor Brn-3ATranscription FactorsGFI1Hair cellsInner ear

Identifiers

PMID32917668
PMCPMC7502595
OpenAlexW3086193895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.