Evidence map›Paper›PMID 32917605›Full record

ArticleScience advances2020

Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates.

Luke Johnson, Ivan Alekseichuk, Jordan Krieg, Alex Doyle, Ying Yu, Jerrold Vitek, Matthew Johnson, Alexander Opitz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 5 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 5 syntheses or guidelines pooled it, 229 citations in OpenAlex.

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  20. Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Luke JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9069-1436
Ivan AlekseichukDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2205-4910
Jordan KriegDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8608-5206
Alex DoyleDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8665-6056
Ying YuDepartment of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.
Jerrold VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2308-6535
Matthew JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9686-5540
Alexander OpitzDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA. aopitz@umn.edu.ORCID 0000-0002-4851-1243
University of Minnesota · US

Funding

Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI EBERLY, LYNN E · 2016 to 2020
$9.1M
Spatiotemporal Optimization of Deep Brain Stimulation for Parkinson's DiseaseR01NS094206 · NINDS · UNIVERSITY OF MINNESOTA · PI Matthew Douglas Johnson, THEODEN I NETOFF · 2016 to 2026
$5.6M
The role of the centromedian and pedunculopontine nuclei in motor function during naïve, parkinsonian and DBS conditionsF31NS108625 · NINDS · UNIVERSITY OF MINNESOTA · PI DOYLE, ALEXANDRA MARIE · 2018 to 2021
$155k
NINDS NIH HHS F31 NS108625NINDS NIH HHS P50 NS098573NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS094206
6 · The paper itself

Abstract

Weak extracellular electric fields can influence spike timing in neural networks. Approaches to noninvasively impose these fields on the brain have high therapeutic potential in neurology and psychiatry. Transcranial alternating current stimulation (TACS) is hypothesized to affect spike timing and cause neural entrainment. However, the conditions under which these effects occur in vivo are unknown. Here, we recorded single-unit activity in the neocortex in awake nonhuman primates during TACS and found dose-dependent neural entrainment to the stimulation waveform. Cluster analysis of changes in interspike intervals identified two main types of neural responses to TACS-increased burstiness and phase entrainment. Our results uncover key mechanisms of TACS and show that the stimulation affects spike timing in the awake primate brain at intensities feasible in humans. Thus, novel TACS protocols tailored to ongoing brain activity may be a tool to normalize spike timing in maladaptive brain networks and neurological disease.

Indexed as

NeocortexTranscranial Direct Current StimulationAnimalsPrimatesWakefulness

Identifiers

PMID32917605
PMCPMC7467690
OpenAlexW3081839143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.