ArticleScience advances2020
Paternal deprivation impairs social behavior putatively via epigenetic modification to lateral septum vasopressin receptor.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Brain neuronal CG9593/ANGPTL4 activation mediates paternally acquired motor disorders.Science advances · 2026Article
- Paternal Deprivation Alters Neural Stem Cells Proliferation and Epigenetic Histone Modifications in the Neurogenic Niches of Adult Prairie Voles.International journal of molecular sciences · 2026Article
- Adolescent social instability stress alters social processes in male prairie voles.Frontiers in behavioral neuroscience · 2026Article
- Differences in auditory brainstem responses between laboratory-reared and wild-caught prairie voles (Microtus ochrogaster).PloS one · 2026Article
- Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus.Psychopharmacology · 2025Article
- Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups.Current biology : CB · 2024Article
- Paternal absence and increased caregiving independently and interactively shape the development of male prairie voles at subadult and adult life stages.Hormones and behavior · 2024Article
- Epigenetic aging studies of pair bonding in prairie voles.Scientific reports · 2024Article
- Biased brain and behavioral responses towards kin in males of a communally breeding species.Scientific reports · 2023Article
- Father's care uniquely influences male neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A circuit from the locus coeruleus to the anterior cingulate cortex modulates offspring interactions in mice.Cell reports · 2023Article
- Transcription and DNA methylation signatures of paternal behavior in hippocampal dentate gyrus of prairie voles.Scientific reports · 2023Article
- Uncovering the brain-wide pattern of synaptic input to vasopressin-expressing neurons in the paraventricular nucleus of the hypothalamus.The Journal of comparative neurology · 2023Article
- Partner separation rescues pair bond-induced decreases in hypothalamic oxytocin neural densities.Scientific reports · 2023Article
- Plasticity in parental behavior and vasopressin: responses to co-parenting, pup age, and an acute stressor are experience-dependent.Frontiers in behavioral neuroscience · 2023Article
- Compensatory enhancement of paternal care in maternally neglected mice family.Animal cells and systems · 2023Article
- Lateral septum DREADD activation alters male prairie vole prosocial and antisocial behaviors, not partner preferences.Communications biology · 2022Article
- Activation of Somatostatin-Expressing Neurons in the Lateral Septum Improves Stress-Induced Depressive-like Behaviors in Mice.Pharmaceutics · 2022Article
- Transcriptomic analysis of paternal behaviors in prairie voles.BMC genomics · 2022Article
- Developmental exposure to intranasal vasopressin impacts adult prairie vole spatial memory.Psychoneuroendocrinology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although it is well appreciated that the early-life social environment asserts subsequent long-term consequences on offspring brain and behavior, the specific mechanisms that account for this relationship remain poorly understood. Using a novel assay that forced biparental pairs or single mothers to prioritize caring for offspring or themselves, we investigated the impact of parental variation on adult expression of nonapeptide-modulated behaviors in prairie voles. We demonstrated that single mothers compensate for the lack of a co-parent. Moreover, mothers choose to invest in offspring over themselves when faced with a tradeoff, whereas fathers choose to invest in themselves. Furthermore, our study suggests a pathway whereby variation in parental behavior (specifically paternal care) may lead to alterations in DNA methylation within the vasopressin receptor 1a gene and gene expression in the lateral septum. These differences are concomitant with changes in social approach, a behavior closely associated with septal vasopressin receptor function.
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