Evidence map›Paper›PMID 32917512›Full record

ReviewPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2020

Zinc: Roles in pancreatic physiology and disease.

Melinda Wang, Madhura Phadke, Daniel Packard, Dhiraj Yadav, Fred Gorelick

Open access · greenAbstract readReview
In one paragraph

Review in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Zinc and Its Impact on the Function of the Testicle and Epididymis.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Article
  11. Hesperidin alleviates zinc-induced nephrotoxicity via the gut-kidney axis in swine.Frontiers in cellular and infection microbiology · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Melinda WangYale School of Medicine, Department of Internal Medicine and VA HealthCare System, CT, USA.
Madhura PhadkeYale School of Medicine, Department of Internal Medicine and VA HealthCare System, CT, USA.
Daniel PackardYale School of Medicine, Department of Internal Medicine and VA HealthCare System, CT, USA.
Dhiraj YadavUniversity of Pittsburgh, Department of Medicine, USA.
Fred GorelickYale School of Medicine, Department of Internal Medicine and VA HealthCare System, CT, USA. Electronic address: Fred.Gorelick@yale.edu.
VA Connecticut Healthcare System · USUniversity of Pittsburgh · US

Funding

Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2014 to 2018
$8.1M
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
EXOCRINE PANCREATIC ZYMOGEN ACTIVATIONR01DK054021 · NIDDK · YALE UNIVERSITY · PI GORELICK, FRED SANFORD · 1998 to 2018
$3.6M
Determinants of Protein Degradation Dynamics in Cell SignalingF32CA180514 · NCI · UNIVERSITY OF WASHINGTON · PI MOSS, BRITNEY LANE · 2013 to 2015
$111k
Regulation of pancreatitis severityI01BX003250 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI Fred Sanford Gorelick · 2016 to 2026
–
BLRD VA I01 BX003250NCI NIH HHS F32 CA180514NIDDK NIH HHS P01 DK098108NIDDK NIH HHS R01 DK054021NIDDK NIH HHS T32 DK007017NIDDK NIH HHS U01 DK108306
6 · The paper itself

Abstract

Zinc is an essential trace element. Deficiencies are frequently seen with gastrointestinal diseases, including chronic pancreatitis, nutritional deficiency, and reduced intestinal absorption. Additionally, reduced zinc levels have been linked to cellular changes associated with acute pancreatitis such as enhanced inflammation with increased macrophage activation and production of inflammatory cytokines such as IL-1β, impaired autophagy, and modulation of calcium homeostasis. Preliminary data suggest that zinc deficiency may lead to pancreatic injury in animal models. The purpose of this review is to explore the biologic effects of zinc deficiency that could impact pancreatic disease. MESH KEYWORDS: Malnutrition, inflammation, trace element.

Indexed as

AnimalsHumansInflammationPancreasPancreatic DiseasesZincZincCytokinePancreatitisZinc

Identifiers

PMID32917512
PMCPMC7572834
OpenAlexW3081545350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.