ReviewTrends in neurosciences2020
Circuit-Based Biomarkers for Mood and Anxiety Disorders.
Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety.Molecular psychiatry · 2026Article
- Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors.Molecular psychiatry · 2026Article
- Uncovering the correlation between neurotransmitter-specific functional connectivity and multidimensional anxiety in a non-clinical cohort.European archives of psychiatry and clinical neuroscience · 2026Article
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025.Molecular brain · 2026Review
- Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics.Frontiers in pharmacology · 2026Review
- Article
- Machine learning-based prediction of anxiety disorders using blood metabolite and social trait data from the UK Biobank.Brain, behavior, & immunity - health · 2025Article
- Effects of Intermittent Fasting on Anxiety and the Functional Connectivity of the Amygdala in Healthy Adults.Alpha psychiatry · 2025Article
- Long-term GABA supplementation mitigates anxiety by modulating complement and neuroinflammatory pathways.NPJ science of food · 2025Article
- Editorial: Neuroimaging in psychiatry 2023: mood disorders.Frontiers in psychiatry · 2025Article
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Article
- Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Neural interfaces: Bridging the brain to the world beyond healthcare.Exploration (Beijing, China) · 2024Article
- Identifying and modulating neural signatures of stress susceptibility and resilience enables control of anhedonia.Research square · 2024Article
- Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat.The international journal of neuropsychopharmacology · 2023Article
- Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network.bioRxiv : the preprint server for biology · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety.Neuroscience bulletin · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.