Evidence map›Paper›PMID 32917166›Full record

ArticleBMC nephrology2020

Effect of renal replacement therapy on selected arachidonic acid derivatives concentration.

Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elżbieta Cecerska-HeryćDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111, Szczecin, Poland. cecerskaela@wp.pl.ORCID 0000-0002-7313-7193
Rafał HeryćDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72, 70-111, Szczecin, Poland.
Magda WiśniewskaDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72, 70-111, Szczecin, Poland.
Natalia SerwinDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111, Szczecin, Poland.
Bartłomiej GrygorcewiczDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111, Szczecin, Poland.
Barbara DołęgowskaDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111, Szczecin, Poland.
Pomeranian Medical University · PL

Funding

NCN 2011/01/B/NZ5/04235Pomorski Uniwersytet Medyczny W Szczecinie MB-134-141/15.
6 · The paper itself

Abstract

backgroundPlatelet activation is an important side effect of dialysis, resulted in a subsequent release of arachidonic acid (AA) from activated platelets. AA is involved in many pathologic conditions, such as inflammation, asthma, cancer, diabetes, hypertension, and the pathogenesis of kidney disease. The aim of this study was to define whether the dialysis type affects the concentration of AA derivatives in patients with chronic kidney disease.

methods117 patients were qualified to the study group. Based on the type of renal replacement therapy, patients were divided into the following groups: hemodialysis (HD A - before/HD B - after hemodialysis), peritoneal dialysis (PD), kidney transplant patients (TE - before/TE A - after transplantation) and conservative treatment (CT) (30; 30; 27; 30 patients, respectively). The control group consisted of 30 healthy volunteers (NK). The ELISA methods were used to measure the concentrations of TXB2, 5-HETE, 12-HETE, and 15-HETE in the blood serum.

resultsRenal replacement therapy significantly influences the concentration of TXB

conclusionsThe type of renal replacement therapy significantly affects the concentration of AA derivatives. Peritoneal dialysis is the best method of dialysis, taking into account the concentration of arachidonic acid derivatives.

Indexed as

12-Hydroxy-5,8,10,14-eicosatetraenoic AcidAgedAged, 80 and overArachidonic AcidCase-Control StudiesConservative TreatmentFemaleHumansHydroxyeicosatetraenoic AcidsKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPeritoneal DialysisRenal DialysisRenal Replacement Therapy12-Hydroxy-5,8,10,14-eicosatetraenoic Acid15-hydroxy-5,8,11,13-eicosatetraenoic acid5-hydroxy-6,8,11,14-eicosatetraenoic acidArachidonic AcidHydroxyeicosatetraenoic AcidsThromboxane B212-HETE15-HETE5-HETEChronic kidney diseaseKidney transplantationRenal replacement therapyThromboxane B2

Identifiers

PMID32917166
PMCPMC7488457
OpenAlexW3084722103

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.