ArticleBMC molecular and cell biology2020
Ommochrome pathway genes kynurenine 3-hydroxylase and cardinal participate in eye pigmentation in Plutella xylostella.
Article in BMC molecular and cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
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- Maintenance of Gut Microbial Balance via the Kynurenine Pathway Improves Larval Performance and Resistance to Bacillus thuringiensis in Spodoptera exigua.MicrobiologyOpen · 2026Article
- Eye can see clearly now: Identifying the locus associated with a white-eye mutation in honey bees (Apis mellifera).Insect molecular biology · 2026Article
- The Role of Pigments in Light Color Variation of the FireflyEcology and evolution · 2025Article
- CRISPR/Cas9 Genome Editing in the Diamondback Moth: Current Progress, Challenges, and Prospects.International journal of molecular sciences · 2025Review
- Pioneering genome editing in parthenogenetic stick insects: CRISPR/Cas9-mediated gene knockout in Medauroidea extradentata.Scientific reports · 2025Article
- Direct Parental (DIPA) CRISPR in the jewel wasp, Nasonia vitripennis.G3 (Bethesda, Md.) · 2024Article
- New Insights into theJournal of agricultural and food chemistry · 2023Review
- Marker-assisted mapping enables forward genetic analysis in Aedes aegypti, an arboviral vector with vast recombination deserts.Genetics · 2022Article
- Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Article
- CRISPR-mediated knockout of cardinal and cinnabar eye pigmentation genes in the western tarnished plant bug.Scientific reports · 2022Article
- Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEye pigmentation genes have been utilized as visible markers for constructing genetic control prototypes in several insect vectors of human disease. Here, orthologs of two ommochrome pathway genes, kynurenine 3-hydroxylase (kmo) and cardinal, were investigated in Plutella xylostella, a globally distributed, economically important pest of Brassica crops.
resultsBoth somatic mosaic and germline mutations were efficiently created using the CRISPR/Cas9 system, and null mutant strains of Pxkmo and Pxcardinal were obtained. A frame-shift mutation in Pxkmo caused yellow compound eyes at adult stage while an in-frame mutation lacking two amino acids resulted in a hypomorphic red eye phenotypes. In contrast, Pxcardinal-deficient moths with a frame-shift mutation exhibited yellow eye pigmentation in newly emerged adults which turned to red as the adults aged. Additionally, differences were observed in the coloration of larval ocelli, brains and testes in Pxkmo and Pxcardinal yellow-eye mutant lines.
conclusionsOur work identifies the important roles of Pxkmo and Pxcardinal in P. xylostella eye pigmentation and provides tools for future genetic manipulation of this important crop pest.
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