Evidence map›Paper›PMID 32917007›Full record

ArticleMolecules (Basel, Switzerland)2020

Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles.

Lisa J White, Jessica E Boles, Kira L F Hilton, Rebecca J Ellaby, Jennifer R Hiscock

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lisa J WhiteSchool of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK.
Jessica E BolesSchool of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK.
Kira L F HiltonSchool of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK.
Rebecca J EllabySchool of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK.
Jennifer R HiscockSchool of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK.ORCID 0000-0002-1406-8802

Funding

Public Health England PhD studentship
6 · The paper itself

Abstract

Herein, we present a series of supramolecular self-associating amphiphilic (SSA) salts and establish the potential for these molecular constructs to act as next-generation solution-state molecular delivery vehicles. We characterise the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, whilst high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-

Indexed as

Drug CarriersAnionsChemistry, OrganicDimerizationDrug Delivery SystemsGasesHydrodynamicsHydrogelsHydrogen BondingLeast-Squares AnalysisMagnetic Resonance SpectroscopyMass SpectrometryParticle SizePolymersSolventsSurface-Active AgentsAnionsDrug CarriersGasesHydrogelsPolymersSolventsSurface-Active Agentsamphiphiledrug deliveryhydrogen bondsupramolecular chemistry

Identifiers

PMID32917007
PMCPMC7570936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.