Evidence map›Paper›PMID 32916947›Full record

ArticleBiomolecules2020

Control of Transcription Initiation by Biased Thermal Fluctuations on Repetitive Genomic Sequences.

Masahiko Imashimizu, Yuji Tokunaga, Ariel Afek, Hiroki Takahashi, Nobuo Shimamoto, David B Lukatsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Masahiko ImashimizuCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.
Yuji TokunagaCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.
Ariel AfekCenter for Genomic and Computational Biology, Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-8584-9879
Hiroki TakahashiMedical Mycology Research Center, Chiba University, Chiba 260-8673, Japan.ORCID 0000-0001-5627-1035
Nobuo ShimamotoNational Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.ORCID 0000-0001-7579-0084
David B LukatskyDepartment of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the process of transcription initiation by RNA polymerase, promoter DNA sequences affect multiple reaction pathways determining the productivity of transcription. However, the question of how the molecular mechanism of transcription initiation depends on the sequence properties of promoter DNA remains poorly understood. Here, combining the statistical mechanical approach with high-throughput sequencing results, we characterize abortive transcription and pausing during transcription initiation by

Indexed as

Transcription, GeneticBase SequenceDNA, BacterialDNA-Directed RNA PolymerasesEntropyEscherichia coliGenomeModels, GeneticPromoter Regions, GeneticRepetitive Sequences, Nucleic AcidRNA, BacterialTemperatureDNA, BacterialDNA-Directed RNA PolymerasesRNA, Bacterialabortive initiationnonlocal base pair stabilitypausingpromoter sequencesrepetitive sequencesRNA polymerasethermal fluctuations

Identifiers

PMID32916947
PMCPMC7564750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.