ArticleBioengineering (Basel, Switzerland)2020
Formulation and Characterization of Alginate Dialdehyde, Gelatin, and Platelet-Rich Plasma-Based Bioink for Bioprinting Applications.
Article in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Bio-inks with PRF Increase Human Osteosarcoma Cell Line (SaOS-2) Viability in Extrusion-Based 3D-Bioprinted Constructs.Annals of biomedical engineering · 2026Article
- An Asymmetric Dura-Inspired Collagen Hydrogel Patch with Integrated Dense-Porous Architecture Enabled by Dual-Channel Freeze Casting.Advanced healthcare materials · 2026Article
- 3D-Printed Alginate Dialdehyde (ADA)-Gelatin (GEL) Hydrogels with Gallic Acid (GA) for Enhanced Multifunctional Properties.ACS omega · 2026Article
- Optimized gradient of lyophilized platelet-rich plasma in biomimetic 3D-printed triphasic scaffold based on alginate and gelatin for osteochondral tissue engineering.Scientific reports · 2026Article
- Integrating platelet-rich plasma therapy into nursing practice: a review of biological mechanisms and clinical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Succinimidyl Alginate-Modified Fibrin Hydrogels from Human Plasma for Skin Tissue Engineering.Gels (Basel, Switzerland) · 2025Article
- Enhancing alginate dialdehyde-gelatin (ADA-GEL) based hydrogels for biofabrication by addition of phytotherapeutics and mesoporous bioactive glass nanoparticles (MBGNs).Journal of biomaterials applications · 2025Article
- Investigating the Effect of Processing and Material Parameters of Alginate Dialdehyde-Gelatin (ADA-GEL)-Based Hydrogels on Stiffness by XGB Machine Learning Model.Bioengineering (Basel, Switzerland) · 2024Article
- ICA/SDF-1α/PBMSCs loaded onto alginate and gelatin cross-linked scaffolds promote damaged cartilage repair.Journal of cellular and molecular medicine · 2024Article
- Physicochemical and Biological Characterization of Gelatin/Alginate Scaffolds Reinforced withInternational journal of biomaterials · 2024Article
- Biomolecules-Loading of 3D-Printed Alginate-Based Scaffolds for Cartilage Tissue Engineering Applications: A Review on Current Status and Future Prospective.The archives of bone and joint surgery · 2024Review
- Smart alginate inks for tissue engineering applications.Materials today. Bio · 2023Review
- Alginate-gelatin hydrogel supplemented with platelet concentrates can be used as bioinks for scaffold printing.Asian biomedicine : research, reviews and news · 2023Article
- Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions.Advanced healthcare materials · 2023Review
- Emerging 3D bioprinting applications in plastic surgery.Biomaterials research · 2023Review
- Blood-derived biomaterials for tissue graft biofabrication by solvent-based extrusion bioprinting.International journal of bioprinting · 2023Review
- 3D-bioprinted human lipoaspirate-derived cell-laden skin constructs for healing of full-thickness skin defects.International journal of bioprinting · 2023Article
- Recent Progress in Bioprinting: From Bioink Design to Applications.Bioengineering (Basel, Switzerland) · 2022Article
- Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing.Bioactive materials · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Layer-by-layer additive manufacturing process has evolved into three-dimensional (3D) "bio-printing" as a means of constructing cell-laden functional tissue equivalents. The process typically involves the mixing of cells of interest with an appropriate hydrogel, termed as "bioink", followed by printing and tissue maturation. An ideal bioink should have adequate mechanical, rheological, and biological features of the target tissues. However, native extracellular matrix (ECM) is made of an intricate milieu of soluble and non-soluble extracellular factors, and mimicking such a composition is challenging. To this end, here we report the formulation of a multi-component bioink composed of gelatin and alginate -based scaffolding material, as well as a platelet-rich plasma (PRP) suspension, which mimics the insoluble and soluble factors of native ECM respectively. Briefly, sodium alginate was subjected to controlled oxidation to yield alginate dialdehyde (ADA), and was mixed with gelatin and PRP in various volume ratios in the presence of borax. The formulation was systematically characterized for its gelation time, swelling, and water uptake, as well as its morphological, chemical, and rheological properties; furthermore, blood- and cytocompatibility were assessed as per ISO 10993 (International Organization for Standardization). Printability, shape fidelity, and cell-laden printing was evaluated using the RegenHU 3D Discovery bioprinter. The results indicated the successful development of ADA-gelatin-PRP based bioink for 3D bioprinting and biofabrication applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.