Evidence map›Paper›PMID 32916815›Full record

ReviewBioengineering (Basel, Switzerland)2020

Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential.

Richard E Decker, Zachary E Lamantia, Todd S Emrick, Marxa L Figueiredo

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Richard E DeckerDepartment of Basic Medical Sciences, Purdue University, 625 Harrison St., West Lafayette, IN 47907, USA.ORCID 0000-0002-6620-8045
Zachary E LamantiaDepartment of Basic Medical Sciences, Purdue University, 625 Harrison St., West Lafayette, IN 47907, USA.
Todd S EmrickDepartment of Polymer Science & Engineering, University of Massachusetts, 120 Governors Drive, Amherst, MA 01003, USA.
Marxa L FigueiredoDepartment of Basic Medical Sciences, Purdue University, 625 Harrison St., West Lafayette, IN 47907, USA.ORCID 0000-0002-8134-0749

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Disrupting tumor/bone malignant interactions with multifunctional cytokine sonodeliveryR01CA196947 · NCI · PURDUE UNIVERSITY · PI FIGUEIREDO, MARXA L · 2016 to 2020
$1.9M
Facilitating Endogenous Bone Repair in Arthritis with Targeted IL-27 SonodeliveryR01AR069079 · NIAMS · PURDUE UNIVERSITY · PI FIGUEIREDO, MARXA L · 2018 to 2022
$1.7M
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA196947NIAMS NIH HHS R01 AR069079NIH HHS R01CA196947, R01AR069079
6 · The paper itself

Abstract

There are currently multiple approaches to facilitate gene therapy via intramuscular gene delivery, such as electroporation, viral delivery, or direct DNA injection with or without polymeric carriers. Each of these methods has benefits, but each method also has shortcomings preventing it from being established as the ideal technique. A promising method, ultrasound-mediated gene delivery (or sonodelivery) is inexpensive, widely available, reusable, minimally invasive, and safe. Hurdles to utilizing sonodelivery include choosing from a large variety of conditions, which are often dependent on the equipment and/or research group, and moderate transfection efficiencies when compared to some other gene delivery methods. In this review, we provide a comprehensive look at the breadth of sonodelivery techniques for intramuscular gene delivery and suggest future directions for this continuously evolving field.

Indexed as

gene therapyintramuscular gene deliverysonodeliverysonoporationultrasound

Identifiers

PMID32916815
PMCPMC7552685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.