Evidence map›Paper›PMID 32916783›Full record

ReviewInternational journal of molecular sciences2020

Epitranscriptomics in Normal and Malignant Hematopoiesis.

Crescenzio Francesco Minervini, Elisa Parciante, Luciana Impera, Luisa Anelli, Antonella Zagaria, Giorgina Specchia, Pellegrino Musto, Francesco Albano

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Crescenzio Francesco MinerviniDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-4382-9906
Elisa ParcianteDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.
Luciana ImperaDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.
Luisa AnelliDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.
Antonella ZagariaDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.
Giorgina SpecchiaFormer Full Professor of Hematology-University of Bari "Aldo Moro", 70124 Bari, Italy.
Pellegrino MustoDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.
Francesco AlbanoDepartment of Emergency and Organ Transplantation (D.E.T.O.)-Hematology and Stem Cell Transplantation Unit-University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-7926-6052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epitranscriptomics analyze the biochemical modifications borne by RNA and their downstream influence. From this point of view, epitranscriptomics represent a new layer for the control of genetic information and can affect a variety of molecular processes including the cell cycle and the differentiation. In physiological conditions, hematopoiesis is a tightly regulated process that produces differentiated blood cells starting from hematopoietic stem cells. Alteration of this process can occur at different levels in the pathway that leads from the genetic information to the phenotypic manifestation producing malignant hematopoiesis. This review focuses on the role of epitranscriptomic events that are known to be implicated in normal and malignant hematopoiesis, opening a new pathophysiological and therapeutic scenario. Moreover, an evolutionary vision of this mechanism will be provided.

Indexed as

Epigenesis, GeneticHematopoiesisTranscriptomeAdenosine DeaminaseAnimalsEpigenomicsEvolution, MolecularHematologic NeoplasmsHumansIntramolecular TransferasesMutationRNA-Binding ProteinsRNA Processing, Post-TranscriptionalADAR protein, humanAdenosine DeaminaseIntramolecular TransferasesPUS7 protein, humanRNA-Binding Proteinsepitranscriptomicshematological malignancieshematopoiesis

Identifiers

PMID32916783
PMCPMC7555315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.