ArticlePloS one2020
Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations.American journal of biological anthropology · 2026Article
- Stress, Well-Being, and Reproduction in Wildlife.Advances in experimental medicine and biology · 2026Review
- Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild.American journal of primatology · 2025Review
- Comparison of age-related inflammation and oxidative stress in two lemur species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Assessment of Oxidative Stress and Biometric Data in a Captive Colony of Hamadryas Baboons (Veterinary sciences · 2025Article
- Costs and constraints of cellular immune activity during development in an arboreal primate.Royal Society open science · 2025Article
- Modulation of cell-mediated immunity during pregnancy in wild bonobos.Biology letters · 2024Article
- Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees.Evolution, medicine, and public health · 2024Article
- Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging.Integrative and comparative biology · 2023Article
- Measures of Oxidative Status Markers in Relation to Age, Sex, and Season in Sick and Healthy Captive Asian Elephants in Thailand.Animals : an open access journal from MDPI · 2023Article
- Neopterin Levels in Bonobos Vary Seasonally and Reflect Symptomatic Respiratory Infections.EcoHealth · 2023Article
- Seasonal patterns of oxidative stress markers in captive Asian elephants in Thailand and relationships to elephant endotheliotropic herpesvirus shedding.Frontiers in veterinary science · 2023Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- Minimally invasive biomarkers in human and non-human primate evolutionary biology: Tools for understanding variation and adaptation.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Female reproduction and viral infection in a long-lived mammal.The Journal of animal ecology · 2022Article
- Methodological confounds of measuring urinary oxidative stress in wild animals.Ecology and evolution · 2022Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- The Kibale Chimpanzee Project: Over thirty years of research, conservation, and change.Biological conservation · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Oxidative stress (OS) plays a marked role in aging and results from a variety of stressors, making it a powerful measure of health and a way to examine costs associated with life history investments within and across species. However, few urinary OS markers have been examined under field conditions, particularly in primates, and their utility to non-invasively monitor the costs of acute stressors versus the long-term damage associated with aging is poorly understood. In this study, we examined variation in 5 urinary markers of oxidative damage and protection under 5 validation paradigms for 37 wild, chimpanzees living in the Kibale National Park, Uganda. We used 924 urine samples to examine responses to acute immune challenge (respiratory illness or severe wounding), as well as mixed-longitudinal and intra-individual variation with age. DNA damage (8-OHdG) correlated positively with all other markers of damage (F-isoprostanes, MDA-TBARS, and neopterin) but did not correlate with protection (total antioxidant capacity). Within individuals, all markers of damage responded to at least one if not both types of acute infection. While OS is expected to increase with age, this was not generally true in chimpanzees. However, significant changes in oxidative damage were detected within past-prime individuals and those close to death. Our results indicate that OS can be measured using field-collected urine and integrates short- and long-term aspects of health. They further suggest that more data are needed from long-lived, wild animals to illuminate if common age-related increases in inflammation and OS damage are typical or recently aberrant in humans.
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Registered trials
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