ArticleJournal of neural engineering2020
Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Biohybrid cochlear implants: neural interfaces, regenerative pathways, and translational benchmarks.Journal of neuroengineering and rehabilitation · 2026Review
- Correlation of Electrical Impedance and Evoked Potentials With Properties of the Electrode Interface Using in Situ Block-Face Imaging of the Rat Pelvic Nerve.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- Bioelectronic Neural Interfaces: Improving Neuromodulation Through Organic Conductive Coatings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- NeurostimML: a machine learning model for predicting neurostimulation-induced tissue damage.Journal of neural engineering · 2024Article
- Article
- PEDOT:PSS-coated platinum electrodes for neural stimulation.APL bioengineering · 2023Article
- NeurostimML: A machine learning model for predicting neurostimulation-induced tissue damage.bioRxiv : the preprint server for biology · 2023Article
- Article
- Cochlear implant material effects on inflammatory cell function and foreign body response.Hearing research · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Real-Time Localization of Cochlear-Implant Electrode Arrays Using Bipolar Impedance Sensing.IEEE transactions on bio-medical engineering · 2022Article
- Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveCochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface of Pt electrodes. The pathophysiological effect of Pt within the cochlea has not been extensively investigated. We previously evaluated the effects of Pt corrosion at high charge densities and reported negligible pathophysiological impact. The present study extends this work by examining techniques that may reduce Pt corrosion. APPROACH: Deafened guinea pigs were continuously stimulated for 28 d using biphasic current pulses at extreme charge densities using: (i) electrode shorting; (ii) electrode shorting with capacitive coupling (CC); or (iii) electrode shorting with alternating leading phase (AP). On completion of stimulation, cochleae were examined for corrosion product, tissue response, auditory nerve (AN) survival and trace levels of Pt; and electrodes examined for surface corrosion. MAIN
resultsPt corrosion was evident at ≥200 μC cm SIGNIFICANCE: Significant increases in tissue response and Pt corrosion were observed following stimulation at high charge densities. Charge recovery using CC, and to a lesser extent AP, reduced the amount of Pt corrosion but not the tissue response. Stimulation at change densities an order of magnitude higher than those used when programming cochlear implant recipients in the clinic, produced a vigorous tissue response and corrosion products without evidence of neural loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.