Evidence map›Paper›PMID 32916172›Full record

ArticleExperimental neurology2020

Differential mechanisms are required for phrenic long-term facilitation over the course of motor neuron loss following CTB-SAP intrapleural injections.

Lauren F Borkowski, Nicole L Nichols

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lauren F BorkowskiDepartment of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, United States of America.
Nicole L NicholsDepartment of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, United States of America. Electronic address: nicholsn@missouri.edu.
University of Missouri · US

Funding

Enhanced respiratory plasticity in models of respiratory motor neuron deathR00HL119606 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI NICHOLS, NICOLE L. · 2015 to 2017
$724k
Enhanced respiratory plasticity in models of respiratory motor neuron deathK99HL119606 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI NICHOLS, NICOLE L. · 2014 to 2014
$104k
NHLBI NIH HHS K99 HL119606NHLBI NIH HHS R00 HL119606
6 · The paper itself

Abstract

Selective elimination of respiratory motor neurons using intrapleural injections of cholera toxin B fragment conjugated to saporin (CTB-SAP) mimics motor neuron death and respiratory deficits observed in rat models of neuromuscular diseases. This CTB-SAP model allows us to study the impact of motor neuron death on the output of surviving phrenic motor neurons. After 7(d) days of CTB-SAP, phrenic long-term facilitation (pLTF, a form of respiratory plasticity) is enhanced, but returns towards control levels at 28d. However, the mechanism responsible for this difference in magnitude of pLTF is unknown. In naïve rats, pLTF predominately requires 5-HT2 receptors, the new synthesis of BDNF, and MEK/ERK signaling; however, pLTF can alternatively be induced via A

Indexed as

AnimalsCholera ToxinLong-Term PotentiationMaleMotor NeuronsPhrenic NervePleural CavityRatsRats, Sprague-DawleySaporinsCholera Toxincholera toxin B-saporin conjugateSaporinsBreathingPhrenic motor neuron deathRespiratory motor outputRespiratory plasticitySpinal cord

Identifiers

PMID32916172
PMCPMC10823911
OpenAlexW3084034523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.