ArticleAge and ageing2021
Social isolation and loneliness as related to progression and reversion of frailty in the Survey of Health Aging Retirement in Europe (SHARE).
Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06875024 (A Series of Studies on Influencing Factors and Intelligent Intervention Programs for Hospitalized Elderly People With Frailty), which is not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Series of Studies on Influencing Factors and Intelligent Intervention Programs for Hospitalized Elderly People With Frailty
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review of Loneliness and Social Isolation Interventions in Obesity and Obesity-Related Complications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Loneliness, social isolation, and living alone: a comprehensive systematic review, meta-analysis, and meta-regression of mortality risks in older adults.Aging clinical and experimental research · 2025Pooled it
- Factors associated with sustained robustness in older adults: an 8-year multinational longitudinal study using SHARE data.BMC geriatrics · 2026Observational
- Association between type 2 diabetes mellitus and psychosocial burdens in older adults in Germany: findings from the longitudinal Gesundheit 65+ study.BMJ open diabetes research & care · 2026Article
- Development and validation of a long-term survival prediction model for older adults with asthma.Archives of public health = Archives belges de sante publique · 2026Article
- Association between chronic gastrointestinal diseases and frailty: unveiling the mediating effect of loneliness.BMC public health · 2025Article
- The mediating role of sarcopenia in the link between loneliness and frailty among nursing home residents: a cross-sectional study.BMC geriatrics · 2025Article
- Assessing Social Interaction and Loneliness and Their Association With Frailty Among Older Adults With Subjective Cognitive Decline or Mild Cognitive Impairment: Ecological Momentary Assessment Approach.JMIR mHealth and uHealth · 2025Article
- Uncovering the impact of loneliness in ageing populations: a comprehensive scoping review.BMC geriatrics · 2025Article
- Associations of social engagement and loneliness with the progression and reversal of frailty: longitudinal investigations of 2 prospective cohorts from the UK and the USA.American journal of epidemiology · 2025Article
- Bidirectional associations between social isolation, loneliness, and cognitive function among Chinese older adults.Journal of global health · 2025Article
- Behavioural and psychological factors associated with pre-frailty in community-dwelling adults aged 40 and over: a cross-sectional study.BMC public health · 2025Article
- Frailty and loneliness among community-dwelling older adults: examining reciprocal associations within a measurement burst design.BMC geriatrics · 2025Article
- Health-related quality of life in hypertensive patients with chronic kidney disease in low and middle-income countries.BMC nephrology · 2025Review
- Human-robot interactions and experiences of staff and service robots in aged care.Scientific reports · 2025Article
- Community-based physical and social activity for older adults with mild frailty: a rapid qualitative study of a collaborative intervention pilot.BMC geriatrics · 2024Article
- Prevention of frailty in relation with social out-of-home activities in older adults: results from the Survey of Health, Ageing, and Retirement in Europe.European journal of ageing · 2024Article
- The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21 years.Age and ageing · 2024Article
- The association between loneliness and frailty among community-dwelling older adults in five European countries: a longitudinal study.Age and ageing · 2024Article
- Frailty and Loneliness in Older Adults: A Narrative Review.Geriatrics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFrailty was shown to be associated with psychosocial risk factors, but there are few longitudinal data.
methodsWe used data from waves 5 and 6 of the Survey of Health Aging Retirement in Europe (SHARE) to study the contribution of loneliness and social isolation to transitions towards frailty defined according to Fried criteria in a sample of 27,468 individuals aged ≥60.
resultsAt baseline, there were 13,069 (47.6%) robust individuals, 11,430 (41.6%) pre-frail and 2,969 (10.8%) frail. After 2 years, among robust subjects at baseline, 8,706 (61.8%) were still robust, 4,033 (30.8%) were pre-frail and 330 (2.6%) were frail. Among those who were pre-frail, 1,504 (13.2%) progressed to frail and 3,557 (31.1%) became robust. Among frail people, 182 (6.1%) reversed to robust and 1,271 (42.8%) to pre-frail. Average and high levels of loneliness and social isolation were significantly associated with the risk of robust people becoming frail and pre-frail (except robust with high loneliness to become frail), and of pre-frail people to become frail (except with average loneliness). Reversion to robustness was inversely associated with high levels of loneliness.
conclusionAverage levels of loneliness and social isolation should not be considered acceptable and should be actively addressed even in the absence of any health conditions through an available evidence-based intervention.
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