Evidence map›Paper›PMID 32915895›Full record

Observational studyPloS one2020

Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement: The FinnValve Study.

Jussi Jaakkola, Samuli Jaakkola, K E Juhani Airaksinen, Annastiina Husso, Tatu Juvonen, Mika Laine, Marko Virtanen, Pasi Maaranen, Matti Niemelä, Timo Mäkikallio and 7 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jussi JaakkolaHeart Center, Turku University Hospital and University of Turku, Turku, Finland.ORCID 0000-0002-3398-4283
Samuli JaakkolaHeart Center, Turku University Hospital and University of Turku, Turku, Finland.
K E Juhani AiraksinenHeart Center, Turku University Hospital and University of Turku, Turku, Finland.
Annastiina HussoHeart Center, Kuopio University Hospital, Kuopio, Finland.
Tatu JuvonenHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Mika LaineHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Marko VirtanenHeart Hospital, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0001-9674-0772
Pasi MaaranenHeart Hospital, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Matti NiemeläDepartment of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Timo MäkikallioDepartment of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Mikko SavontausHeart Center, Turku University Hospital and University of Turku, Turku, Finland.
Tuomas TauriainenResearch Unit of Surgery, Anesthesiology and Critical Care, University of Oulu, Oulu, Finland.
Antti ValtolaHeart Center, Kuopio University Hospital, Kuopio, Finland.
Antti VentoHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Markku EskolaHeart Hospital, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Peter RaivioHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Fausto BiancariHeart Center, Turku University Hospital and University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whether the subtype of atrial fibrillation affects outcomes after transcatheter aortic valve replacement for aortic stenosis is unclear. The nationwide FinnValve registry included 2130 patients who underwent primary after transcatheter aortic valve replacement for aortic stenosis during 2008-2017. Altogether, 281 (13.2%) patients had pre-existing paroxysmal atrial fibrillation, 651 (30.6%) had pre-existing non-paroxysmal atrial fibrillation and 160 (7.5%) were diagnosed with new-onset atrial fibrillation during the index hospitalization. The median follow-up was 2.4 (interquartile range: 1.6-3.8) years. Paroxysmal atrial fibrillation did not affect 30-day or overall mortality (p-values >0.05). Non-paroxysmal atrial fibrillation demonstrated an increased risk of overall mortality (hazard ratio: 1.61, 95% confidence interval: 1.35-1.92; p<0.001), but not 30-day mortality (p = 0.084). New-onset atrial fibrillation demonstrated significantly increased 30-day mortality (hazard ratio: 2.76, 95% confidence interval: 1.25-6.09; p = 0.010) and overall mortality (hazard ratio: 1.68, 95% confidence interval: 1.29-2.19; p<0.001). The incidence of early or late stroke did not differ between atrial fibrillation subtypes (p-values >0.05). In conclusion, non-paroxysmal atrial fibrillation and new-onset atrial fibrillation are associated with increased mortality after transcatheter aortic valve replacement for aortic stenosis, whereas paroxysmal atrial fibrillation has no effect on mortality. These findings suggest that non-paroxysmal atrial fibrillation rather than paroxysmal atrial fibrillation may be associated with structural cardiac damage which is of prognostic significance in patients with aortic stenosis undergoing transcatheter aortic valve replacement.

Indexed as

Transcatheter Aortic Valve ReplacementAgedAged, 80 and overAortic Valve StenosisAtrial FibrillationCohort StudiesFemaleFinlandHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMalePostoperative ComplicationsPrognosisRegistriesRetrospective Studies

Identifiers

PMID32915895
PMCPMC7485765

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.