Evidence map›Paper›PMID 32915674›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Heart Rate Reduction Improves Right Ventricular Function and Fibrosis in Pulmonary Hypertension.

Ryo Ishii, Kenichi Okumura, Yohei Akazawa, Manpreet Malhi, Ryota Ebata, Mei Sun, Tao Fujioka, Hideyuki Kato, Osami Honjo, Golam Kabir and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Cardioprotective Properties of Kaempferol: A Review.Plants (Basel, Switzerland) · 2023
    Review
  11. Review
  12. Heart Rate Reduction by Ivabradine: Slowly but Surely?American journal of respiratory cell and molecular biology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ryo IshiiThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Kenichi OkumuraThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Yohei AkazawaThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Manpreet MalhiDepartment of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Canada.
Ryota EbataThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Mei SunThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Tao FujiokaThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Hideyuki KatoThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Osami HonjoThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
Golam KabirThe Keenan Research Center for Biomedical Research of St. Michael's Hospital, Toronto, Canada; and.
Wolfgang M KueblerInstitute of Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Kim ConnellyThe Keenan Research Center for Biomedical Research of St. Michael's Hospital, Toronto, Canada; and.
Jason T MaynesDepartment of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Canada.
Mark K FriedbergThe Labatt Family Heart Center, Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children and University of Toronto, Toronto, Canada.
University of Toronto · CAHospital for Sick Children · CASt. Michael's Hospital · CACharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential benefit of heart rate reduction (HRR), independent of β-blockade, on right ventricular (RV) function in pulmonary hypertension (PH) remains undecided. We studied HRR effects on RV fibrosis and function in PH and RV pressure-loading models. Adult rats were randomized to

Indexed as

AnimalsHeart RateHeart VentriclesHemodynamicsHumansHypertension, PulmonaryInduced Pluripotent Stem CellsIvabradinePulmonary ArteryRats, Sprague-DawleyVentricular Function, RightVentricular PressureIvabradineexperimentalheart ratepulmonary arterial hypertensionright ventricleright ventricular pressure loading

Identifiers

PMID32915674
OpenAlexW3086947178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.