ArticleBiotechnology and bioengineering2021
Dynamics of microbial competition, commensalism, and cooperation and its implications for coculture and microbiome engineering.
Article in Biotechnology and bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Challenges and Future Directives of Synthetic Biology in Engineering Plant-Microbe Partnerships for Sustainable Agriculture.Biotechnology and bioengineering · 2026Review
- Different co-culture approaches to increase metabolites in foods.Food science and biotechnology · 2026Review
- Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives.Biotechnology and bioengineering · 2026Review
- Direct valorization of agricultural byproducts to vanillin by a synergistic Komagataella phaffii co-culture system.Biotechnology for biofuels and bioproducts · 2026Article
- Hypersensitivity of chitin degradation to initial species densities due to monomer diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Community matters: stress tolerance and survival ofFrontiers in microbiology · 2026Article
- Numerical simulation and governance framework for multi stakeholder symbiotic evolution in digital innovation ecosystems.Scientific reports · 2025Article
- Nanoparticles in liposomes: a platform for increased antibiotic selectivity in multidrug resistant bacteria in respiratory tract infections.Drug delivery and translational research · 2025Article
- Article
- Metaproteomic and gene expression analysis of interspecies interactions in a PAH-degrading synthetic microbial consortium constructed with the key microbes of a natural consortium.Biodegradation · 2023Article
- Microbiome engineering for bioremediation of emerging pollutants.Bioprocess and biosystems engineering · 2023Review
- Engineering living materials by synthetic biology.Biophysics reviews · 2023Review
- A Two-Compartment Fermentation System to Quantify Strain-Specific Interactions in Microbial Co-Cultures.Bioengineering (Basel, Switzerland) · 2023Article
- Microbiome distribution modeling using gradient descent strategies for mock, in vitro and clinical community distributions.PloS one · 2023Article
- Engineering microbial consortia with rationally designed cellular interactions.Current opinion in biotechnology · 2022Review
- Engineering anaerobic digestion via optimizing microbial community: effects of bactericidal agents, quorum sensing inhibitors, and inorganic materials.Applied microbiology and biotechnology · 2021Review
- Dynamics of microbial competition, commensalism, and cooperation and its implications for coculture and microbiome engineering.Biotechnology and bioengineering · 2021Article
- Unstructured kinetic models to simulate an arabinose switch that decouples cell growth from metabolite production.Synthetic and systems biotechnology · 2020Article
- Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch.Metabolic engineering communications · 2020Article
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Abstract
Microbial consortium is a complex adaptive system with higher-order dynamic characteristics that are not present by individual members. To accurately predict the social interactions, we formulate a set of unstructured kinetic models to quantitatively capture the dynamic interactions of multiple microbial species. By introducing an interaction coefficient, we analytically derived the steady-state solutions for the interacting species and the substrate-depleting profile in the chemostat. We analyzed the stability of the possible coexisting states defined by competition, parasitism, amensalism, commensalism, and cooperation. Our model predicts that only parasitism, commensalism, and cooperation could lead to stable coexisting states. We also determined the optimal social interaction criteria of microbial coculture when sequential metabolic reactions are compartmentalized into two distinct species. Coupled with Luedeking-Piret and Michaelis-Menten equations, accumulation of metabolic intermediates in one species and formation of end-product in another species could be derived and assessed. We discovered that parasitism consortia disfavor the bioconversion of intermediate to final product; and commensalism consortia could efficiently convert metabolic intermediates to final product and maintain metabolic homeostasis with a broad range of operational conditions (i.e., dilution rates); whereas cooperative consortia leads to highly nonlinear pattern of precursor accumulation and end-product formation. The underlying dynamics and emergent properties of microbial consortia may provide critical knowledge for us to understand ecological coexisting states, engineer efficient bioconversion process, deliver effective gut therapeutics as well as elucidate probiotic-pathogen or tumor-host interactions in general.
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