Evidence map›Paper›PMID 32915425›Full record

ArticleChinese journal of integrative medicine2020

Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16

Jue Wang, Yin-Yin Ying, Zhao-Hui Chen, Ke-Ding Shao, Wei-Ping Zhang, Sheng-You Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Chinese journal of integrative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  8. Guilu-Erxian-Glue alleviatesPharmaceutical biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jue WangDepartment of Oncology, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China.
Yin-Yin YingDepartment of Oncology, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China.
Zhao-Hui ChenDepartment of Oncology, Ningbo Forth Hospital, Ningbo, Zhejiang Province, 315700, China.
Ke-Ding ShaoScience Research Department, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Wei-Ping ZhangDepartment of Oncology, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China.
Sheng-You LinDepartment of Oncology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, China. linsy0628@163.com.
The Third Affiliated Hospital of Zhejiang Chinese Medical University · CNHangzhou Hospital of Traditional Chinese Medicine · CNNingbo No.6 Hospital · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of Guilu Erxian Glue (, GEG) on cyclophosphamide (CTX)-induced bone marrow hematopoietic stem cells (HSCs) senescence in mice and explore the underlying mechanism.

methodsThe H

resultsCompared with the model group, GEG increased cell viability as well as proliferation (P<0.05 or P<0.01) and reduced β -gal expression. Furthermore, GEG significantly decreased the expressions of p16

conclusionGEG can alleviate CTX-induced HSCs senescence in mice, and the p16

Indexed as

AnimalsAntineoplastic Agents, AlkylatingBone MarrowCell CycleCell Line, TumorCell SurvivalCellular SenescenceCyclin-Dependent Kinase Inhibitor p16CyclophosphamideDisease Models, AnimalDrugs, Chinese HerbalHematopoietic Stem CellsMaleMiceAntineoplastic Agents, AlkylatingCyclin-Dependent Kinase Inhibitor p16CyclophosphamideDrugs, Chinese Herbalbone marrow suppressionChinese medicineGuilu Erxian Gluehematopoietic stem cell senescencep16INK4a

Identifiers

PMID32915425
OpenAlexW3086721270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.