Evidence map›Paper›PMID 32915368›Full record

Observational studyClinical and experimental nephrology2021

Serum uromodulin is a novel renal function marker in the Japanese population.

Ryosuke Usui, Tetsuya Ogawa, Hideo Takahashi, Chihiro Iwasaki, Minako Koike, Taku Morito, Michiyasu Hatano, Kosaku Nitta

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryosuke UsuiDivision of Nephrology, Department of Medicine, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owadashinden, Yachiyo city, Chiba, 276-8524, Japan. usui.ryosuke@twmu.ac.jp.
Tetsuya OgawaDepartment of Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Hideo TakahashiMinami-Akatsuka Clinic, Ibaraki, Japan.
Chihiro IwasakiDivision of Nephrology, Department of Medicine, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owadashinden, Yachiyo city, Chiba, 276-8524, Japan.
Minako KoikeDivision of Nephrology, Department of Medicine, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owadashinden, Yachiyo city, Chiba, 276-8524, Japan.
Taku MoritoDepartment of Medicine, Division of Nephrology, Yokohama Rosai Hospital, Kanagawa, Japan.
Michiyasu HatanoDepartment of Medicine, Division of Nephrology, Yokohama Rosai Hospital, Kanagawa, Japan.
Kosaku NittaDepartment of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUromodulin, also known as Tamm-Horsfall protein, is the most abundant protein in urine. It has recently been reported that uromodulin exists in a small amount in blood and that its concentration correlates with the estimated glomerular filtration rate (eGFR).

methodsFirst, we generated anti-human uromodulin mouse monoclonal antibodies (mAb(s)) and established a specific enzyme-linked immunosorbent assay (ELISA) for uromodulin. We then performed an observational clinical study to determine if there was a correlation between serum uromodulin concentration and estimates of kidney function and whether the serum uromodulin value could be a biomarker in clinical nephrology. The clinical study included 308 patients with and without chronic kidney disease and healthy volunteers. Serum concentrations of creatinine, cystatin C, and uromodulin were measured and correlations were sought between the eGFR calculated from the creatinine and cystatin C levels and the serum uromodulin concentration.

resultsThere was a good correlation between the serum uromodulin concentration and the eGFR value calculated from the creatinine (r = 0.76) and cystatin C (r = 0.79) levels. The mean serum uromodulin level in the group with an eGFR > 90 mL/min/1.73 m

conclusionsThe serum uromodulin measurement could be a useful biomarker for identification of patients with early deterioration of kidney function.

Indexed as

Glomerular Filtration RateAdultAgedBiomarkersCase-Control StudiesCreatinineCystatin CDisease ProgressionFemaleHumansJapanMaleMiddle AgedRenal Insufficiency, ChronicUromodulinBiomarkersCreatinineCystatin CUromodulinBiomarkerCKDKidney functionTamm–horsfall proteinUromodulin

Identifiers

PMID32915368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.