Evidence map›Paper›PMID 32915360›Full record

ArticleObesity surgery2020

Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass.

Silvia Leite Faria, Andrey Santos, Daniéla Oliveira Magro, Everton Cazzo, Heloisa Balan Assalin, Dioze Guadagnini, Flavio Teixeira Vieira, Eliane Said Dutra, Mario José Abdalla Saad, Marina K Ito

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In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Silvia Leite Faria *Departament of Human Nutrition, University of Brasilia, Brasilia, DF, Brazil.
Andrey Santos *Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Rua Tessália Vieira de Camargo, 126 Cidade Universitária Zeferino Vaz, Campinas, SP, 13084-971, Brazil. andreysts@gmail.com.ORCID http://orcid.org/0000-0003-2922-3032
Daniéla Oliveira MagroDepartment of Surgery, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
Everton CazzoDepartment of Surgery, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
Heloisa Balan AssalinDepartment of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Rua Tessália Vieira de Camargo, 126 Cidade Universitária Zeferino Vaz, Campinas, SP, 13084-971, Brazil.
Dioze GuadagniniDepartment of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Rua Tessália Vieira de Camargo, 126 Cidade Universitária Zeferino Vaz, Campinas, SP, 13084-971, Brazil.
Flavio Teixeira VieiraDepartament of Human Nutrition, University of Brasilia, Brasilia, DF, Brazil.
Eliane Said DutraDepartament of Human Nutrition, University of Brasilia, Brasilia, DF, Brazil.
Mario José Abdalla SaadDepartment of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Rua Tessália Vieira de Camargo, 126 Cidade Universitária Zeferino Vaz, Campinas, SP, 13084-971, Brazil.
Marina K ItoDepartament of Human Nutrition, University of Brasilia, Brasilia, DF, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe relationship between late post-bariatric surgery weight regain and gut microbiota is not completely understood.

objectiveTo analyze the profile of gut microbiota among patients with and without late weight regain after post-Roux-en-Y gastric bypass (RYGB) and to compare it with a control group (CG) comprised of obese Brazilian individuals.

methodsThis is a cross-sectional study which enrolled 34 morbidly obese women divided into 3 groups: post-Roux-en-Y gastric bypass without (RYGB_non-regain), and with weight regain (RYGB_regain) at least 5 years after surgery, and a CG of preoperative individuals. Gut microbiota was determined by metagenomic analyses.

resultsThe alpha diversity was higher in groups RYGB non-regain and RYGB regain when compared with CG (p < 0.05). Both RYGB non-regain and RYGB regain groups showed a lower abundance of the phylum Bacteroidetes when compared with CG (p < 0.01). The genera Bacteroides and SMB53 were increased in CG (p < 0.05). Group RYGB non-regain showed more abundance of the Akkermansia genus when compared with CG and group RYGB regain (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and lower of the SMB53 genus when compared with CG (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and a lower of the SMB53 genus when compared with CG (p < 0.05).

conclusionThe gut microbiota of individuals which presented late weight regain after RYGB was significantly different in comparison to individuals with a successful weight loss, a finding that points towards a significant role of gut microbiota on weight loss and maintenance after surgery.

Indexed as

Gastric BypassGastrointestinal MicrobiomeObesity, MorbidBrazilCross-Sectional StudiesFemaleHumansWeight GainBariatric surgeryGastric bypassMicrobiotaObesityWeight loss

Identifiers

PMID32915360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.