Evidence map›Paper›PMID 32915353›Full record

ArticleJournal of neuro-oncology2020

Serum microRNA is a biomarker for post-operative monitoring in glioma.

Andrew Morokoff, Jordan Jones, Hong Nguyen, Chenkai Ma, Arian Lasocki, Frank Gaillard, Iwan Bennett, Rod Luwor, Stanley Stylli, Lucia Paradiso and 12 more

Erratum issued 2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06203496 recruitingnot on this mapstarted 2024, after this paper: background citation

Monitoring of Patients With Diffuse Gliomas Using Circulating miRNAs

TypeobservationalSponsorUniversity Hospital, CaenRan2024 to 2026Enrolled60ConditionsGlioma, MalignantArmsBlood sample
NCT06610851 recruitingnot on this mapstarted 2024, after this paper: background citation

Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA

TypeobservationalSponsorUniversity Hospital, CaenRan2024 to 2030Enrolled20ConditionsGlioma, miRNA, Low-grade Glioma, BiomarkersArmsBlood sample
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  13. Advances in applications of artificial intelligence algorithms for cancer-related miRNA research.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
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  19. Cell-Free miRNAs as Non-Invasive Biomarkers in Brain Tumors.Diagnostics (Basel, Switzerland) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Andrew MorokoffDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia. morokoff@unimelb.edu.au.ORCID http://orcid.org/0000-0002-5159-3438
Jordan JonesDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Hong NguyenDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Chenkai MaDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Arian LasockiDepartment of Radiology, University of Melbourne, Parkville, VIC, Australia.
Frank GaillardDepartment of Radiology, University of Melbourne, Parkville, VIC, Australia.
Iwan BennettDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Rod LuworDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Stanley StylliDepartment of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia.
Lucia ParadisoDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Rachel KoldejDepartment of Medicine, University of Melbourne, Parkville, VIC, Australia.
Iddo PaldorDepartment of Neurosurgery, Royal Melbourne Hospital, Parkville, VIC, Australia.
Ramyar MolaniaWalter and Eliza Hall Institute, Parkville, VIC, Australia.
Terence P SpeedWalter and Eliza Hall Institute, Parkville, VIC, Australia.
Andrew WebbWalter and Eliza Hall Institute, Parkville, VIC, Australia.
Guiseppe InfusiniWalter and Eliza Hall Institute, Parkville, VIC, Australia.
Jason LiPeter MacCallum Cancer Centre, Parkville, VIC, Australia.
Charles MalpasClinical Outcomes Research Unit, Royal Melbourne Hospital, Parkville, VIC, Australia.
Tomas KalincikClinical Outcomes Research Unit, Royal Melbourne Hospital, Parkville, VIC, Australia.
Katharine DrummondDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
Tali SiegalNeuro-Oncology, Davidoff Institute of Oncology, Rabin Medical Center, Petach Tikva, Israel.
Andrew H KayeDepartment of Surgery, University of Melbourne, Parkville, VIC, Australia.
The University of Melbourne · AUThe Royal Melbourne Hospital · AUWalter and Eliza Hall Institute of Medical Research · AUPeter MacCallum Cancer Centre · AURabin Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA circulating biomarker has potential to provide more accurate information for glioma progression post treatment, however no such biomarker is currently available. We aimed to discover a microRNA serum biomarker for longitudinal monitoring of glioma patients.

methodsA prospectively collected cohort of 91 glioma patients and 17 healthy controls underwent pre and post-operative serum miRNA profiling using Nanostring®. Differentially expressed miRNAs were discovered using a machine learning random forest analysis. Candidate miRNAs were then assessed by droplet digital PCR in 11 patients with multiple follow up samples and compared to tumor volume based on magnetic resonance imaging.

resultsA 9-gene miRNA signature was identified that could distinguish between glioma and healthy controls with 99.8% accuracy. Two miRNAs miR-223 and miR-320e, best demonstrated dynamic changes that correlated closely with tumor volume in LGG and GBM respectively. Importantly, miRNA levels did not increase in two cases of pseudo-progression, indicating the potential utility of this test in guiding treatment decisions.

conclusionsWe identified a highly accurate 9-miRNA signature associated with glioma serum. Additionally, we observed dynamic changes in specific miRNAs correlating with tumor volume over long-term follow up. These results support a large prospective validation study of serum miRNA biomarkers in glioma.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorBrain NeoplasmsFemaleFollow-Up StudiesGene Expression ProfilingGene Expression Regulation, NeoplasticGliomaHumansMaleMicroRNAsMiddle AgedNeoplasm Recurrence, LocalPrognosisBiomarkers, TumorMicroRNAsBiomarkersGlioblastomaGliomaLiquid biopsymiRNA

Identifiers

PMID32915353
OpenAlexW3086276576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.