Evidence map›Paper›PMID 32915323›Full record

ArticleCancer causes & control : CCC2020

Investigating the associations of glycemic load and glycemic index with lung cancer risk in the Southern Community Cohort Study.

Xiang Shu, Danxia Yu, Xiao-Ou Shu, Heather M Munro, Wei Zheng, William J Blot

Abstract read
In one paragraph

Article in Cancer causes & control : CCC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. ShuX@mskcc.org.ORCID http://orcid.org/0000-0002-4129-9403
Danxia YuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Heather M MunroInternational Epidemiology Institute, Rockville, MD, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Uncovering Roles of Metabolites in Colorectal Cancer EtiologyR00CA230205 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SHU, XIANG · 2020 to 2022
$888k
Uncovering roles of metabolites in colorectal cancer etiologyK99CA230205 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIANG · 2019 to 2020
$194k
NCI NIH HHS K99 CA230205NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA068485NCI NIH HHS R00 CA230205NCI NIH HHS U01 CA202979NIH HHS K99 CA230205-01A1NIH HHS U01 CA202979Vanderbilt-Ingram Cancer Center P30 CA68485
6 · The paper itself

Abstract

purposeDiets with a high glycemic load (GL) or glycemic index (GI) may increase cancer risk. Findings from prior studies on the relationship between GL, GI, and lung cancer risk are inconsistent. We investigated this relationship in a large prospective cohort.

methodsWe analyzed data from the Southern Community Cohort Study, a prospective cohort that includes diverse racial groups predominantly low-income adults aged 40-79 in 12 southeastern states of the USA. We estimated dietary GL and GI values using data collected from food frequency questionnaires at baseline. Dietary GL and GI were energy adjusted by residual method and categorized into sex-specific quintiles. Cox proportional hazard regression was used to assess the associations between dietary GL, GI, and lung cancer risk. We further performed stratified analyses by various factors.

resultsIntakes of individual food items or food groups that commonly contribute to GL were similar between blacks and whites in the cohort. After excluding the first two years of follow-up, 947 incident lung cancers were ascertained among 55,068 participants. Neither dietary GL nor GI was significantly associated with incident lung cancer risk in the overall population (GL: Q5 vs. Q1, HR = 0.88, 95% CI 0.72-1.07, p

conclusionDietary GL and GI were not independently associated with incident lung cancer risk in a large understudied population.

Indexed as

Glycemic IndexGlycemic LoadAdultAgedCohort StudiesFemaleHumansLung NeoplasmsMaleMiddle AgedUnited StatesBlacksGlycemic indexGlycemic loadLung cancer riskSocioeconomic status

Identifiers

PMID32915323
PMCPMC7572706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.