ArticleCerebral cortex (New York, N.Y. : 1991)2021
Greater BOLD Variability is Associated With Poorer Cognitive Function in an Adult Lifespan Sample.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Trial
- Age-related changes in behavioural and neural variability in a decision-making task.Nature communications · 2026Article
- Article
- Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- Distributed fMRI patterns coupled to low-frequency cardiorespiratory dynamics provide markers of aging.bioRxiv : the preprint server for biology · 2025Article
- Functional PET for mapping metabolic dynamics in Parkinson's disease.Scientific reports · 2025Article
- Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025Review
- Variability Rather Than Means? Harnessing the Adversary to Advance Precision Psychiatry.The American journal of psychiatry · 2025Article
- Impact of hearing loss on brain signal variability in older adults under different auditory load conditions.Frontiers in aging neuroscience · 2025Article
- Comparing and scaling fMRI features for brain-behavior prediction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dynamic fluctuations of intrinsic brain activity are associated with consistent topological patterns in puberty and are biomarkers of neural maturation.Network neuroscience (Cambridge, Mass.) · 2025Article
- Imbalanced temporal states of cortical blood-oxygen-level-dependent signal variability during rest in episodic migraine.The journal of headache and pain · 2024Article
- Reliability of variability and complexity measures for task and task-free BOLD fMRI.Human brain mapping · 2024Article
- Cortical thickness moderates intraindividual variability in prefrontal cortex activation patterns of older adults during walking.Journal of the International Neuropsychological Society : JINS · 2024Article
- Neural variability in three major psychiatric disorders.Molecular psychiatry · 2023Article
- Relation of resting brain signal variability to cognitive and socioemotional measures in an adult lifespan sample.Social cognitive and affective neuroscience · 2023Article
- From local properties to brain-wide organization: A review of intraregional temporal features in functional magnetic resonance imaging data.Human brain mapping · 2023Review
- Network-level permutation entropy of resting-state MEG recordings: A novel biomarker for early-stage Alzheimer's disease?Network neuroscience (Cambridge, Mass.) · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Moment-to-moment fluctuations in brain signal assessed by functional magnetic resonance imaging blood oxygenation level dependent (BOLD) variability is increasingly thought to represent important "signal" rather than measurement-related "noise." Efforts to characterize BOLD variability in healthy aging have yielded mixed outcomes, demonstrating both age-related increases and decreases in BOLD variability and both detrimental and beneficial associations. Utilizing BOLD mean-squared-successive-differences (MSSD) during a digit n-back working memory (WM) task in a sample of healthy adults (aged 20-94 years; n = 171), we examined effects of aging on whole-brain 1) BOLD variability during task (mean condition MSSD across 0-2-3-4 back conditions), 2) BOLD variability modulation to incrementally increasing WM difficulty (linear slope from 0-2-3-4 back), and 3) the association of age-related differences in variability with in- and out-of-scanner WM performance. Widespread cortical and subcortical regions evidenced increased mean variability with increasing age, with no regions evidencing age-related decrease in variability. Additionally, posterior cingulate/precuneus exhibited increased variability to WM difficulty. Notably, both age-related increases in BOLD variability were associated with significantly poorer WM performance in all but the oldest adults. These findings lend support to the growing corpus suggesting that brain-signal variability is altered in healthy aging; specifically, in this adult lifespan sample, BOLD-variability increased with age and was detrimental to cognitive performance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.