Evidence map›Paper›PMID 32914957›Full record

ArticleACS applied materials & interfaces2020

X-ray-Induced Cherenkov Optical Triggering of Caged Doxorubicin Released to the Nucleus for Chemoradiation Activation.

Cuiping Yao, Jiong Li, Xu Cao, Jason R Gunn, Ming Wu, Shudong Jiang, Brian W Pogue

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Light-Sensitive Phenacyl Crosslinked Dextran Hydrogels for Controlled Delivery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Cuiping YaoThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.ORCID http://orcid.org/0000-0002-7110-0696
Jiong LiInstitute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, 710049 Xi'an, Shaanxi, China.
Xu CaoThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Jason R GunnThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Ming WuThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China.ORCID http://orcid.org/0000-0001-8326-4076
Shudong JiangThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.ORCID http://orcid.org/0000-0002-9887-670X
Dartmouth College · USFujian Medical University · CNXi'an Jiaotong University · CN

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Cerenkov excited luminescence sheet imaging (CELSI)R01EB024498 · NIBIB · DARTMOUTH COLLEGE · PI POGUE, BRIAN WILLIAM · 2017 to 2020
$2.2M
NCI NIH HHS P30 CA023108NIBIB NIH HHS R01 EB024498
6 · The paper itself

Abstract

Concurrent chemoradiotherapy is used for advanced cancers, but the chemotherapy is dose limited by normal tissue toxicity. Localized X-ray activation of chemotherapy could overcome this, as studied here, with release from self-assembled nanomicelles (NMs) created from copolymers loaded with doxorubicin (DOX) having a photocleavable

Indexed as

X-RaysAnimalsAntibiotics, AntineoplasticCell NucleusCell ProliferationDoxorubicinDrug LiberationDrug Screening Assays, AntitumorHumansMiceMice, Inbred BALB CMicellesMice, NudeMolecular StructureNeoplasms, ExperimentalParticle SizeAntibiotics, AntineoplasticDoxorubicinMicellesCherenkovfolic acidirradiationnanoparticlesnanotechnologytheranosticX-ray

Identifiers

PMID32914957
PMCPMC10851348
OpenAlexW3085806713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.