ArticleJournal of clinical laboratory analysis2020
Ammonia predicts poor outcomes in patients with hepatitis B virus-related acute-on-chronic liver failure.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Serum ammonia variation predicts mortality in patients with hepatitis B virus-related acute-on-chronic liver failure.Frontiers in microbiology · 2023Article
- Clinical Prediction Models for Hepatitis B Virus-related Acute-on-chronic Liver Failure: A Technical Report.Journal of clinical and translational hepatology · 2021Article
- Ammonia predicts poor outcomes in patients with hepatitis B virus-related acute-on-chronic liver failure.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatic encephalopathy (HE) is a common feature of acute liver failure and has been reported to be associated with poor outcomes. Ammonia is thought to be central to the pathogenesis of HE, but its role in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is unclear. The present study aimed to assess the prognostic role of ammonia level for patients with HBV-ACLF.
methodsWe retrospectively recruited 127 patients diagnosed with HBV-ACLF for the present study.
resultsAmmonia levels at the time of admission were higher among non-surviving participants than in survivors. Increased ammonia level was found to be associated with severe liver disease and was identified as an independent predictor for mortality in patients with HBV-ACLF.
conclusionsOur results suggest that high ammonia level at admission is an independent factor for predicting short-term mortality in patients with HBV-ACLF. Therefore, ammonia levels may represent a therapeutic target for this condition.
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