Evidence map›Paper›PMID 32914830›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2021

Interaction of Neighborhood and Genetic Risk on Waist Circumference in African-American Adults: A Longitudinal Study.

Tyler McDaniel, Dawn K Wilson, M Sandra Coulon, Allison M Sweeney, M Lee Van Horn

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01025726 (Improving Safety and Access for Physical Activity), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01025726 nacompletednot on this map

Improving Safety and Access for Physical Activity

TypeinterventionalSponsorUniversity of South CarolinaRan2007 to 2012Enrolled439ConditionsObesityArmsPolice Patrolled Walking plus Social Marketing, Police Patrolled Walking Program Only, General Health Education
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Social determinants of health and selection bias in genome-wide association studies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tyler McDanielDepartment of Psychology, Barnwell College, University of South Carolina, Columbia, SC, USA.
Dawn K WilsonDepartment of Psychology, Barnwell College, University of South Carolina, Columbia, SC, USA.
M Sandra CoulonDepartment of Mental Health, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
Allison M SweeneyDepartment of Psychology, Barnwell College, University of South Carolina, Columbia, SC, USA.
M Lee Van HornDepartment of Educational Psychology, University of New Mexico, Albuquerque, NM, USA.
University of South Carolina · USRalph H. Johnson VA Medical Center · USUniversity of New Mexico · US

Funding

Improving safety and access for physical activity supplementR01DK067615 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILSON, DAWN K · 2007 to 2010
$3.2M
NIDDK NIH HHS R01 DK067615
6 · The paper itself

Abstract

backgroundUnderstanding determinants of metabolic risk has become a national priority given the increasingly high prevalence rate of this condition among U.S. adults. PURPOSE: This study's aim was to assess the impact of gene-by-neighborhood social environment interactions on waist circumference (WC) as a primary marker of metabolic risk in underserved African-American adults. Based on a dual-risk model, it was hypothesized that those with the highest genetic risk and who experienced negative neighborhood environment conditions would demonstrate higher WC than those with fewer risk factors.

methodsThis study utilized a subsample of participants from the Positive Action for Today's Health environmental intervention to improve access and safety for walking in higher-crime neighborhoods, who were willing to provide buccal swab samples for genotyping stress-related genetic pathways. Assessments were conducted with 228 African-American adults at baseline, 12, 18, and 24 months.

resultsAnalyses indicated three significant gene-by-environment interactions on WC outcomes within the sympathetic nervous system (SNS) genetic pathway. Two interactions supported the dual-risk hypotheses, including the SNS genetic risk-by-neighborhood social life interaction (b = -0.11, t(618) = -2.02, p = .04), and SNS genetic risk-by-informal social control interaction (b = -0.51, t(618) = -1.95, p = .05) on WC outcomes. These interactions indicated that higher genetic risk and lower social-environmental supports were associated with higher WC. There was also one significant SNS genetic risk-by-neighborhood satisfaction interaction (b = 1.48, t(618) = 2.23, p = .02) on WC that was inconsistent with the dual-risk pattern.

conclusionsFindings indicate that neighborhood and genetic factors dually influence metabolic risk and that these relations may be complex and warrant further study.

trial registrationNCT01025726.

Indexed as

Black or African AmericanGene-Environment InteractionResidence CharacteristicsSocial EnvironmentWaist CircumferenceAdultAgedCardiometabolic Risk FactorsFemaleGenetic Predisposition to DiseaseHumansLongitudinal StudiesMaleMiddle AgedObesityPersonal SatisfactionAfrican AmericansGenetic riskNeighborhood social factorsWaist circumference

Identifiers

PMID32914830
PMCPMC8311785
OpenAlexW3085514931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.