ArticleeLife2020
Dichotomous role of the human mitochondrial Na
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Molecular mechanisms of mitochondrial CaNature communications · 2026Article
- Mitophagy and Ubiquitination Coordinate Context-Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Molecular mechanisms of mitochondrial CabioRxiv : the preprint server for biology · 2026Article
- Mitochondria-ER crosstalk via MAMS: Bridging cellular homeostasis and cancer progression.Apoptosis : an international journal on programmed cell death · 2026Review
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- Mitochondrial CaJournal of cellular physiology · 2025Review
- Mitochondrial metabolism and cancer therapeutic innovation.Signal transduction and targeted therapy · 2025Review
- TMEM65 functions as the mitochondrial NaNature cell biology · 2025Article
- Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway.Science signaling · 2025Article
- Crosstalk between calcium and reactive oxygen species signaling in cancer revisited.Cell calcium · 2025Review
- TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux.Nature metabolism · 2025Article
- S-acylation of CaChronic diseases and translational medicine · 2024Review
- Dysregulation of calcium homeostasis in cancer and its role in chemoresistance.Cancer drug resistance (Alhambra, Calif.) · 2024Review
- Article
- Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX.Oncology letters · 2023Article
- NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness.The EMBO journal · 2023Article
- Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced CaCell death discovery · 2023Article
- Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance.Journal of neurochemistry · 2023Article
- Article
- Post-translational modifications and protein quality control of mitochondrial channels and transporters.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 2 institutions in 2 countries.
Trayambak Pathak *Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Maxime Gueguinou *Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Vonn WalterDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, United States.ORCID http://orcid.org/0000-0001-6114-6714
Celine DelierneuxDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Martin T JohnsonDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Ping XinDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Ryan E YoastDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Scott M EmrichDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Gregory S YochumDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, United States.
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID http://orcid.org/0000-0002-7550-1550
Walter A KoltunDepartment of Surgery, Division of Colon and Rectal Surgery, The Pennsylvania State University College of Medicine, Hershey, United States.
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Nadine HempelDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, United States.ORCID https://orcid.org/0000-0001-6759-864X
Pennsylvania State University · USBen-Gurion University of the Negev · IL
Funding
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MReceptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MRegulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancerR01CA242021 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEMPEL, NADINE · 2020 to 2024
$1.8MLeukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5MGenes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471kThe Mitochondrial Sodium/Calcium Exchanger (NCLX) in Airway Smooth Muscle Remodeling during AsthmaF30HL147489 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JOHNSON, MARTIN T · 2019 to 2022
$149kAmerican Heart Association 9POST34380606NCI NIH HHS R01 CA242021NHLBI NIH HHS F30 HL147489NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NHLBI NIH HHS R35 HL150778NIA NIH HHS R21 AG050072NIGMS NIH HHS R35 GM131916
Abstract
Despite the established role of mitochondria in cancer, the mechanisms by which mitochondrial Ca
Indexed as
AnimalsCalciumColonColorectal NeoplasmsFemaleHumansMaleMiceMice, KnockoutMitochondriaMitochondrial ProteinsNeoplasm MetastasisSodium-Calcium ExchangerCalciumMitochondrial ProteinsSLC8B1 protein, humanSodium-Calcium Exchangercalcium signalingColorectal cancerHIF1ahumanmetastasismitochondrial calciummolecular biophysicsmousestructural biology
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.