Evidence map›Paper›PMID 32914677›Full record

SynthesisJournal of dental research2021

Oral Manifestations in Patients with COVID-19: A Living Systematic Review.

J Amorim Dos Santos, A G C Normando, R L Carvalho da Silva, A C Acevedo, G De Luca Canto, N Sugaya, A R Santos-Silva, E N S Guerra

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05311410 (Viral Kinetics of SARS-CoV-2 in Patients in the Intensive Care Unit Undergoing Dental Procedures), which is not on this map. Cited by 130 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 14 pooled it
40.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05311410 naunknown statusnot on this map

Viral Kinetics of SARS-CoV-2 in Patients in the Intensive Care Unit Undergoing Dental Procedures

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2021 to 2025Enrolled60ConditionsSARS-CoV2 Infection, Viral Load, Oral Diseases, Dental TreatmentArmsNon-bloody dental procedures (control group), Bloody dental procedures (study group)
3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 14 syntheses or guidelines pooled it, 315 citations in OpenAlex.

  1. Pooled it
  2. Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  13. Oral mucosal lesions in patients with COVID-19: a systematic review.The British journal of oral & maxillofacial surgery · 2021
    Pooled it
  14. Pooled it
  15. Review
  16. Article
  17. Review
  18. Oral and maxillofacial manifestations of COVID-19.GMS hygiene and infection control · 2026
    Review
  19. Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

J Amorim Dos SantosLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil.
A G C NormandoLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil.
R L Carvalho da SilvaLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil.
A C AcevedoLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil.
G De Luca CantoBrazilian Centre for Evidence-Based Research, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil.
N SugayaStomatology Department, School of Dentistry, University of São Paulo, São Paulo, Brazil.
A R Santos-SilvaOral Diagnosis, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2040-6617
E N S GuerraLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil.ORCID https://orcid.org/0000-0002-7622-1550
Universidade de Brasília · BRUniversidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This living systematic review aims to summarize evidence on the prevalence of oral signs and symptoms in patients with COVID-19. The review was reported per the PRISMA checklist, and the literature search was conducted in 6 databases and in gray literature. Studies published in any language mentioning oral symptoms and signs in patients with COVID-19 were included. The risk of bias was assessed by the Joanna Briggs Institute appraisal tools. The certainty of evidence was evaluated through GRADE assessment. After a 2-step selection, 40 studies were included: 33 cross-sectional and 7 case reports. Overall, 10,228 patients (4,288 males, 5,770 females, and 170 unknown) from 19 countries were assessed. Gustatory impairment was the most common oral manifestation, with a prevalence of 45% (95% CI, 34% to 55%;

Indexed as

COVID-19Cross-Sectional StudiesFemaleHumansMaleMouth DiseasesMouth MucosaPrevalenceTaste Disorderscoronavirus infectionsevidence-based medicinegustatory dysfunctionmeta-analysisoral-systemic disease(s)systematic reviews

Identifiers

PMID32914677
OpenAlexW3085707530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.