ArticleJournal of the American Heart Association2020
Long-Term Clinical Outcomes of Nonhyperemic Pressure Ratios: Resting Full-Cycle Ratio, Diastolic Pressure Ratio, and Instantaneous Wave-Free Ratio.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05250557 (Prognostic Impact of Lesion-specific Hemodynamic Index and Disease Characteristics in Patients With Coronary Artery Disease Assessed by Fractional Flow Reserve), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Impact of Lesion-specific Hemodynamic Index and Disease Characteristics in Patients With Coronary Artery Disease Assessed by Fractional Flow Reserve
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Outcomes Following Discordance Between Fractional Flow Reserve and Instantaneous Wave-Free Ratio in Deferred Coronary Lesions: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Impact of coronary revascularization on clinical outcomes in vessels with discordant results of fractional flow reserve and resting full-cycle ratio.Heart and vessels · 2026Article
- Prognostic Impact of Lesion-Specific Hemodynamic Index and Disease Characteristics in Patients with Coronary Artery Disease Assessed by Diastolic Hyperemia-Free Ratio and Instantaneous Wave-Free Ratio (PRIME-DFRiFR).Acta Cardiologica Sinica · 2025Article
- Interpretation of Discordance Between Non-Hyperemic Pressure Ratios and Fractional Flow Reserve: Potential Mechanisms and Clinical Implications.Reviews in cardiovascular medicine · 2025Review
- Sex Differences in 5-Year Outcomes After Deferral of Revascularization Following Physiological Coronary Assessment.Circulation reports · 2024Article
- Prognostic Implications of Individual and Combinations of Resting and Hyperemic Coronary Pressure and Flow Parameters.JACC. Asia · 2023Article
- Invasive physiologic assessment of coronary artery stenosis by resting full-cycle ratio and fractional flow reserve: a prospective observational study.Scientific reports · 2023Observational
- Prognostic impact of resting full-cycle ratio and diastolic non-hyperemic pressure ratios in patients with deferred revascularization.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Prognosis and Medical Cost of Measuring Fractional Flow Reserve in Percutaneous Coronary Intervention.JACC. Asia · 2022Article
- Clinical use of physiological lesion assessment using pressure guidewires: an expert consensus document of the Japanese association of cardiovascular intervention and therapeutics-update 2022.Cardiovascular intervention and therapeutics · 2022Review
- Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction.Frontiers in cardiovascular medicine · 2022Review
- Association of Echocardiographic Diastolic Dysfunction with Discordance of Invasive Intracoronary Pressure Indices.Journal of clinical medicine · 2021Article
- Exploring diastolic pressure ratio to fractional flow reserve discordance and a hypothesis on tailoring diastolic pressure ratio cut-off values to improve diagnostic accuracy in the mid- and distal-LAD.International journal of cardiology. Heart & vasculature · 2021Article
- Comparison of Resting Full-Cycle Ratio and Fractional Flow Reserve in a German Real-World Cohort.Frontiers in cardiovascular medicine · 2021Article
- Long-Term Clinical Outcomes of Nonhyperemic Pressure Ratios: Resting Full-Cycle Ratio, Diastolic Pressure Ratio, and Instantaneous Wave-Free Ratio.Journal of the American Heart Association · 2020Article
- Nonhyperemic Pressure Ratios Versus Fractional Flow Reserve: What to Do With Discordant Results?Journal of the American Heart Association · 2020Article
- Functional assessment of coronary stenosis: alternative hyperemic, nonhyperemic, and angiographic indexes.REC, interventional cardiologyReview
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18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background Nonhyperemic pressure ratios (NHPRs) such as instantaneous wave-free ratio, resting full-cycle ratio, or diastolic pressure ratio have emerged as invasive physiologic indices precluding the need for hyperemic agents. The current study sought to evaluate the long-term prognostic implications of NHPRs compared with fractional flow reserve (FFR). Methods and Results NHPRs were calculated from resting pressure tracings by an independent core laboratory in 1024 vessels (435 patients). The association between NHPRs and the risk of 5-year vessel-oriented composite outcomes (VOCO, a composite of cardiac death, vessel-related myocardial infarction, and ischemia-driven revascularization) were analyzed among 864 deferred vessels. Lesions with positive NHPRs (instantaneous wave free ratio, resting full-cycle ratio, and diastolic pressure ratio ≤0.89) or FFR (≤0.80) showed significantly higher risk of VOCO at 5 years than those with negative NHPRs or FFR, respectively. Discriminant ability for 5-year VOCO was not different among NHPRs and FFR (C-index: 0.623-0.641,
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