Evidence map›Paper›PMID 32914257›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2021

Olfactory function in patients with obstructive sleep apnea: a meta-analysis study.

Giannicola Iannella, Giuseppe Magliulo, Antonino Maniaci, Giuseppe Meccariello, Salvatore Cocuzza, Giovanni Cammaroto, Riccardo Gobbi, Rossella Sgarzani, Elisabetta Firinu, Ruggero Massimo Corso and 12 more

Open access · greenAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. A Review of a Recent Meta-Analysis Study on Obstructive Sleep Apnea.Journal of rhinology : official journal of the Korean Rhinologic Society · 2022
    Review
  13. Anxiety, depression and sleepiness in OSA patients treated with barbed reposition pharyngoplasty: a prospective study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Observational
  14. Article
  15. Postoperative respiratory complications in children with obstructive sleep apnoea syndrome.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022
    Article
  16. Olfactory dysfunction is associated with cognitive impairment in patients with obstructive sleep apnea: a cross-sectional study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
  17. Obstructive Sleep Apnea Syndrome: From Symptoms to Treatment.International journal of environmental research and public health · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 1 country.

Giannicola IannellaOtolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy. giannicola.iannella@uniroma1.it.ORCID http://orcid.org/0000-0003-1781-2809
Giuseppe MagliuloDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy.
Antonino ManiaciENT Section, Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 78, 95125, Catania, Italy.
Giuseppe MeccarielloOtolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy.
Salvatore CocuzzaENT Section, Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 78, 95125, Catania, Italy.
Giovanni CammarotoOtolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy.
Riccardo GobbiOtolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy.
Rossella SgarzaniDepartment of Emergency, Burn Center, Bufalini Hospital, Azienda USL Della Romagna, viale Giovanni Ghirotti, 286, 47521, Cesena, Italy.
Elisabetta FirinuOtolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forlì, Italy.
Ruggero Massimo CorsoIntensive Care Unit, Morgagni-Pierantoni Hospital, AUSL of Romagna, Via Carlo Forlanini, 34, 47121, Forlì, Italy.
Annalisa PaceDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy.
Giampiero GulottaDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy.
Irene Claudia ViscontiDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy.
Milena Di LucaENT Section, Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 78, 95125, Catania, Italy.
Stefano PelucchiDepartment ENT and Audiology, University of Ferrara, Via Savonarola, 9, 44121, Ferrara, Italy.
Giulia BianchiDepartment ENT and Audiology, University of Ferrara, Via Savonarola, 9, 44121, Ferrara, Italy.
Michela MelegattiDepartment ENT and Audiology, University of Ferrara, Via Savonarola, 9, 44121, Ferrara, Italy.
Pietro AbitaUnit of Otorhinolaryngology, Department of Adult and Development Age Human Pathology "Gaetano Barresi", University of Messina, Messina, Italy.
Carmen SolitoDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy.
Ignazio La MantiaENT Section, Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 78, 95125, Catania, Italy.
Calogero GrilloENT Section, Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 78, 95125, Catania, Italy.
Claudio ViciniDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy.
Ospedale G.B. Morgagni - L.Pierantoni · ITSapienza University of Rome · ITUniversity of Catania · ITUniversity of Ferrara · ITAzienda Unità Sanitaria Locale Della Romagna · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis meta-analysis study was designed to analyze the olfactory function in obstructive sleep apnea patients (OSA).

methodsA comprehensive review of the English language literature regarding OSA patients and olfactory function/dysfunction was performed. The papers assessing olfactory dysfunction with Sniffin' Sticks test were taken into consideration.

resultsA total of 420 OSA patients were judged eligible for the study. The average TDI score was found to be 24.3 ± 5.6. The olfactory identification (OD), the olfactory discrimination (OD), and the olfactory threshold (OT) average values were calculated resulting 9.9 ± 2.1, 9.8 ± 1.5, and 5.3 ± 2, respectively. There were 161 healthy control subjects in this meta-analysis. The average TDI of the control group was 30.7 ± 6.0 showing a statistical difference with the group of OSA patients (p = 0.03). A linear correlation between Apnea-Hypopnea Index (AHI) increase and TDI decrease (R

conclusionThe comparison between OSA patients and healthy subjects using Sniffin' Sticks test showed lower values of the various olfactory parameters. Although a linear correlation between AHI increase and olfactory dysfunction was observed, no statistical difference between mild-moderate and severe OSA patients in terms of the severity of olfactory dysfunction could be proved.

Indexed as

Olfaction DisordersSleep Apnea, ObstructiveHealthy VolunteersHumansSmellCholinergic disordersObstructive sleep apneaOlfactory functionSniffin’ Sticks test

Identifiers

PMID32914257
OpenAlexW3084936548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.