ArticleBrain structure & function2020
Influences of age and pubertal status on number and intensity of perineuronal nets in the rat medial prefrontal cortex.
Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Perineuronal nets preferentially surround parvalbumin interneurons in the prelimbic cortex: A rat and mouse comparison.Brain research · 2026Article
- Parvalbumin and anxiety across development in female offspring of the MAM neurodevelopmental model of schizophrenia.Journal of psychiatric research · 2026Article
- Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026Review
- Sexually dimorphic organization of extracellular matrix and perineuronal nets in the prairie vole (Microtus ochrogaster) social brain.Brain structure & function · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Perineuronal nets in the developing brain: implications for neurodevelopmental disorders.Molecular brain · 2025Review
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications.Journal of neurochemistry · 2025Review
- Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus).The Journal of comparative neurology · 2025Article
- Age- and sex-dependent effects of stressors on activity of the nucleus reuniens of the thalamus.Schizophrenia research · 2025Article
- Distribution of perineuronal nets in the adult rat neocortex.Somatosensory & motor research · 2025Article
- Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Enhanced fear extinction through infralimbic perineuronal net digestion: The modulatory role of adolescent alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2025Article
- Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats.Developmental neuroscience · 2025Article
- Prelimbic cortex perineuronal net expression and social behavior: Impact of adolescent intermittent ethanol exposure.Neuropharmacology · 2025Article
- Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits.Advances in experimental medicine and biology · 2025Review
- Enhanced Fear Extinction Through Infralimbic Perineuronal Net Digestion: The Modulatory Role of Adolescent Alcohol Exposure.bioRxiv : the preprint server for biology · 2024Article
- Zinc-a2-Glycoprotein Acts as a Component of PNN to Protect Hippocampal Neurons from Apoptosis.Molecular neurobiology · 2024Article
- The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty.Developmental psychobiology · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The prefrontal cortex (PFC) is a late developing region of the cortex, and its protracted maturation during adolescence may confer a period of plasticity. Closure of critical, or sensitive, periods in sensory cortices coincides with perineuronal net (PNN) expression, leading to enhanced inhibitory function and synaptic stabilization. PNN density has been found to increase across adolescence in the male rat medial PFC (mPFC). Here, we examined both male and female rats at four time points spanning adolescent development to stereologically quantify the number and intensity of PNNs in the mPFC. Additionally, because puberty coincides with broad behavioral and neuroanatomical changes, we collected tissue from age-matched pre- and post-pubertal siblings within a litter. Results indicate that both males and females show an increase in the total number and intensity of mPFC PNNs between postnatal day (P) 30 and P60. As we have previously found, white matter under the mPFC also increased at the same time. Male puberty did not affect PNNs, while female pubertal onset led to an abrupt decrease in the total number of PNNs that persisted through mid-adolescence before increasing at P60. Despite the change in PNN number, the intensity of female PNNs was not affected by puberty. Thus, though males and females show increases in mPFC PNNs during adolescence, the pubertal decrease in the number of PNNs in female rats may indicate a difference in the pattern of maximal plasticity between the sexes during adolescence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.