SynthesisNeurosurgical review2021
Olfactory outcomes after endonasal skull base surgery: a systematic review.
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Middle turbinate preservation versus resection during endoscopic sinus surgery: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Partial Middle Turbinate Resection Versus Preservation on Olfactory Function: A Systematic Review and Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialePooled it
- Changes in olfactory function and olfactory bulb after treatment for acromegaly.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Trial
- Olfactory-Related Quality of Life After Endoscopic Transsphenoidal Surgery.Laryngoscope investigative otolaryngology · 2026Article
- Association between Objective and Subjective Olfactory Dysfunction in SARS-CoV-2-Positive Patients Undergoing Skull Base Surgery.Journal of neurological surgery. Part B, Skull base · 2026Article
- Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus.Clinical reviews in allergy & immunology · 2026Review
- A triple-layer, autograft-free reconstruction strategy for skull base repair after standard endoscopic endonasal resection of pituitary adenomas.Frontiers in surgery · 2026Article
- Significant Underreporting of Preoperative Hyposmia in Patients Undergoing Endoscopic Skull Base Surgery: Discrepancies Between Subjective and Objective Measurements.Journal of neurological surgery. Part B, Skull base · 2024Article
- Effect of endoscopic endonasal skull base approaches on olfactory function and facial development in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Comparison of Sinonasal Outcomes in Patients Undergoing Uni-nostril and Bi-nostril Endoscopic Trans-sphenoidal Excision of Pituitary Adenomas: A Prospective Study.Journal of neurological surgery. Part B, Skull base · 2024Article
- Incidence and influencing factors of olfactory dysfunction in patients 1 week after endoscopic transsphenoidal resection of pituitary tumor: a cross-sectional study of 158 patients.Frontiers in neurology · 2024Article
- Effects of Endoscopic Sinus Surgery on Olfactory Function.Current allergy and asthma reports · 2023Review
- Olfactory changes after endonasal endoscopic cerebrospinal fluid fistula repair: long-term outcomes.The Journal of laryngology and otology · 2023Article
- Is nasal airflow disrupted after endoscopic skull base surgery? A short review.Neurosurgical review · 2022Review
- One-and-a-half nostril versus binostril endoscopic transsphenoidal approach to the pituitary adenomas: A prospective randomized controlled trial.Frontiers in surgery · 2022Article
- Nasal Obstruction Symptom Evaluation Score Analysis: Exploring Nasal Function in Premenopausal versus Postmenopausal Indian Women.Journal of mid-life healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the last two decades, endonasal approach has been regularly applied to treat skull base lesions. However, postoperative olfactory dysfunction remains an unsolved problem. This systematic review aimed to identify factors that might affect postoperative olfactory prognosis of patients undergoing endonasal surgery for resection of sellar/parasellar lesions. The literature search was conducted comprehensively to exhaust studies which focused on patients' olfaction with objective olfactory assessments after endonasal skull base surgery. We sought to characterize the potential factors that might affect postoperative olfactory outcomes. Nineteen articles met inclusion criteria. We found that (1) endoscopic surgery was beneficial to patients' olfactory prognosis than microscopic surgery (incidence of postoperative decreased olfactory function: 18.48% (39/211) for the endoscopic group and 36.88% (52/141) for the microscopic group, P < 0.01); meta-analysis for single rate, 20% (95% CI 9-30%) for the endoscopic group and 35% (95% CI 0-72%) for the microscopic group); (2) harvesting septal flaps was an unfavorable factor for olfactory recovery and the rescue flap technique should be preferred compared with the HB flap; (3) no evidence showed that resection of the middle turbinate was detrimental to recovery of olfaction. Patients undergoing endoscopic endonasal surgery may have better olfactory outcomes than those undergoing microscopic endonasal surgery for resection of sellar/parasellar lesions. Special attention should be paid when using septal flaps is planned and the rescue flap technique should be the preferred choice. After resecting the middle turbinate, patients' olfaction still has a great chance of returning to the baseline. More homogeneous and high-quality studies are needed for further assessment.
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Registered trials
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