Evidence map›Paper›PMID 32914219›Full record

ArticleArchives of toxicology2020

Impact of iron oxide nanoparticles on xenobiotic metabolism in HepaRG cells.

Linn Voss, Kiymet Yilmaz, Lea Burkard, Janja Vidmar, Valerie Stock, Ute Hoffmann, Oliver Pötz, Helen Sophie Hammer, Matthias Peiser, Albert Braeuning and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Linn VossGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Kiymet YilmazGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Lea BurkardGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Janja VidmarNational Food Institute, Technical University of Denmark, Kemitorvet, Building 201, 2800 Kgs, Lyngby, Denmark.
Valerie StockGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Ute HoffmannDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Auerbachstr. 112, 70376, Stuttgart, Germany.
Oliver PötzSIGNATOPE GmbH, Markwiesenstraße 55, 72770, Reutlingen, Germany.
Helen Sophie HammerSIGNATOPE GmbH, Markwiesenstraße 55, 72770, Reutlingen, Germany.
Matthias PeiserGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Albert BraeuningGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Katrin LöschnerNational Food Institute, Technical University of Denmark, Kemitorvet, Building 201, 2800 Kgs, Lyngby, Denmark.
Linda BöhmertGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany. linda.boehmert@bfr.bund.de.
Holger SiegGerman Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589, Berlin, Germany. holger.sieg@bfr.bund.de.ORCID http://orcid.org/0000-0002-0593-0173
Federal Institute for Risk Assessment · DESignatope GmbH (Germany)Technical University of Denmark · DKDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron oxide nanoparticles are used in various industrial fields, as a tool in biomedicine as well as in food colorants, and can therefore reach human metabolism via oral uptake or injection. However, their effects on the human body, especially the liver as one of the first target organs is still under elucidation. Here, we studied the influence of different representative iron oxide materials on xenobiotic metabolism of HepaRG cells. These included four iron oxide nanoparticles, one commercially available yellow food pigment (E172), and non-particulate ionic control FeSO

Indexed as

Basic Helix-Loop-Helix ProteinsBiotransformationConstitutive Androstane ReceptorCytochrome P-450 Enzyme SystemDown-RegulationGene Expression Regulation, EnzymologicHepatocytesHep G2 CellsHumansIsoenzymesMagnetic Iron Oxide NanoparticlesMolecular StructureParticle SizePregnane X ReceptorReceptors, Aryl HydrocarbonReceptors, Cytoplasmic and NuclearAHR protein, humanBasic Helix-Loop-Helix ProteinsConstitutive Androstane ReceptorCytochrome P-450 Enzyme SystemIsoenzymesNR1I2 protein, humanPregnane X ReceptorReceptors, Aryl HydrocarbonReceptors, Cytoplasmic and NuclearXenobioticsIron oxide nanoparticlesLiverNanotechnologyToxicityXenobiotic metabolism

Identifiers

PMID32914219
OpenAlexW3085801771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.