Evidence map›Paper›PMID 32914211›Full record

ArticlePflugers Archiv : European journal of physiology2020

Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.

Gulzar Alam, Zhilin Luan, Aneesa Gul, Heyuan Lu, Yunfeng Zhou, Xiaoxiao Huo, Yaqing Li, Chunxiu Du, Zhaokang Luo, Haibo Zhang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Role of FXR in Renal Physiology and Kidney Diseases.International journal of molecular sciences · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Gulzar AlamAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Zhilin LuanAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Aneesa GulAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Heyuan LuAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yunfeng ZhouMedical Research Center, Department of Physiology at the Basic Medical College, Shenzhen University Health Science Center, Shenzhen, 518060, China.
Xiaoxiao HuoAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yaqing LiAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Chunxiu DuAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Zhaokang LuoAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Haibo ZhangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Hu XuAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Feng ZhengAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Youfei GuanAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China. guanyf@dmu.edu.cn.
Xiaoyan ZhangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China. wserien@163.com.
Dalian Medical University · CNDalian University of Technology · CNShenzhen University Health Science Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crystallin zeta (CRYZ) is a phylogenetically restricted water-soluble protein and provides cytoprotection against oxidative stress via multiple mechanisms. Increasing evidence suggests that CRYZ is high abundantly expressed in the kidney where it acts as a transacting factor in increasing glutaminolysis and the Na

Indexed as

AnimalsCells, CulturedCytoplasmKidney Tubules, CollectingMaleMiceMice, Inbred C57BLOsmotic PressureReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearResponse Elementszeta-CrystallinsReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearzeta-CrystallinsCrystallinFXRGene knockoutNuclear receptorOxidative stress

Identifiers

PMID32914211
OpenAlexW3086691458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.