ArticlePersonality neuroscience2020
Posttraumatic stress symptomatology and abnormal neural responding during emotion regulation under cognitive demands: mediating effects of personality.
Article in Personality neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Differential adolescent neurodevelopment of emotion processing across internalizing psychopathology and childhood adversity.Developmental cognitive neuroscience · 2026Article
- Reading speed, visual deficits, and cerebral white matter integrity in veterans with and without mild traumatic brain injury.Frontiers in neuroscience · 2026Article
- Posttraumatic stress symptomatology rather than mild traumatic brain injury is related to atypical early neural processing during cognitive control.Neuropsychology · 2025Article
- Frontal Pole Neuromodulation for Impulsivity and Suicidality in Veterans With Mild Traumatic Brain Injury and Common Co-Occurring Mental Health Conditions: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2024Article
- From E-Commerce to the Metaverse: A Neuroscientific Analysis of Digital Consumer Behavior.Behavioral sciences (Basel, Switzerland) · 2024Article
- Shades of Rage: Applying the Process Model of Emotion Regulation to Managing Anger After Brain Injury.Frontiers in psychology · 2022Review
- Emotional Activity Is Negatively Associated With Cognitive Load in Multimedia Learning: A Case Study With EEG Signals.Frontiers in psychology · 2022Article
- Connecting quantitatively derived personality-psychopathology models and neuroscience.Personality neuroscience · 2021Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is often complicated by the after-effects of mild traumatic brain injury (mTBI). The mixture of brain conditions results in abnormal affective and cognitive functioning, as well as maladaptive behavior. To better understand how brain activity explains cognitive and emotional processes in these conditions, we used an emotional N-back task and functional magnetic resonance imaging (fMRI) to study neural responses in US military veterans after deployments to Iraq and Afghanistan. Additionally, we sought to examine whether hierarchical dimensional models of maladaptive personality could account for the relationship between combat-related brain conditions and fMRI responses under cognitive and affective challenge. FMRI data, measures of PTSD symptomatology (PTSS), blast-induced mTBI (bmTBI) severity, and maladaptive personality (MMPI-2-RF) were gathered from 93 veterans. Brain regions central to emotion regulation were selected for analysis, and consisted of bilateral amygdala, bilateral dorsolateral prefrontal (dlPFC), and ventromedial prefrontal/subgenual anterior cingulate (vmPFC-sgACC). Cognitive load increased activity in dlPFC and reduced activity in emotional responding brain regions. However, individuals with greater PTSS showed blunted deactivations in bilateral amygdala and vmPFC-sgACC, and weaker responses in right dlPFC. Additionally, we found that elevated emotional/internalizing dysfunction (EID), specifically low positive emotionality (RC2), accounted for PTSS-related changes in bilateral amygdala under increased cognitive load. Findings suggest that PTSS might result in amygdala and vmPFC-sgACC activity resistant to moderation by cognitive demands, reflecting emotion dysregulation despite a need to marshal cognitive resources. Anhedonia may be an important target for interventions that improve the affective and cognitive functioning of individuals with PTSD.
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Registered trials
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