ArticleBioactive materials2021
Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- A Novel Strategy for Achieving Immunomodulation and Osseointegration of Titanium Alloys: Boron-Doped Porous Coating Modification.Advanced healthcare materials · 2026Article
- Effect of Voltage and Deposition Time on Surface Morphology, Mechanical Performance, and Corrosion Resistance of Chitosan-Nanohydroxyapatite Coatings.Materials (Basel, Switzerland) · 2026Article
- Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings.Nanomaterials (Basel, Switzerland) · 2025Article
- Exploring the potential of laser-textured metal alloys: Fine-tuning vascular cells responses throughBioactive materials · 2025Article
- Wound Closure Promotion by Leucine-Based Pseudo-Proteins: An In Vitro Study.International journal of molecular sciences · 2024Article
- Nano-Enhanced Phase Reinforced Magnesium Matrix Composites: A Review of the Matrix, Reinforcement, Interface Design, Properties and Potential Applications.Materials (Basel, Switzerland) · 2024Review
- Article
- Enhancing angiogenesis in peri-implant soft tissue with bioactive silk fibroin microgroove coatings on zirconia surfaces.Regenerative biomaterials · 2024Article
- Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration.Molecules (Basel, Switzerland) · 2023Article
- A paradigm for high-throughput screening of cell-selective surfaces coupling orthogonal gradients and machine learning-based cell recognition.Bioactive materials · 2023Article
- Electrodeposited Zinc Coatings for Biomedical Application: Morphology, Corrosion and Biological Behaviour.Materials (Basel, Switzerland) · 2023Review
- Leucine-Based Pseudo-Proteins (LPPs) as Promising Biomaterials: A Study of Cell-Supporting Properties.Polymers · 2023Article
- Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Stability, biomechanics and biocompatibility analysis following different preparation strategies of hierarchical zeolite coatings on titanium alloy surfaces.Frontiers in bioengineering and biotechnology · 2023Article
- Influence of Surface Roughness on Biodegradability and Cytocompatibility of High-Purity Magnesium.Materials (Basel, Switzerland) · 2022Article
- Surface engineering and the application of laser-based processes to stents - A review of the latest development.Bioactive materials · 2022Review
- Titanium Nanobowl-Based Nest-Like Nanofiber Structure Prepared at Room Temperature and Pressure Promotes Osseointegration of Beagle Implants.Frontiers in bioengineering and biotechnology · 2022Article
- Artificial Extracellular Matrices Containing Bioactive Glass Nanoparticles Promote Osteogenic Differentiation in Human Mesenchymal Stem Cells.International journal of molecular sciences · 2021Article
- Adapting the Pore Size of Individual, 3D-Printed CPC Scaffolds in Maxillofacial Surgery.Journal of clinical medicine · 2021Article
- Challenges and strategies forBioactive materials · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinctively directing endothelial cells (ECs) and smooth muscle cells (SMCs), potentially by surface topography cue, is of central importance for enhancing bioefficacy of vascular implants. For the first time, surface gradients with a broad range of nano-micrometer roughness are developed on Mg, a promising next-generation biodegradable metal, to carry out a systematic study on the response of ECs and SMCs. Cell adhesion, spreading, and proliferation are quantified along gradients by high-throughput imaging, illustrating drastic divergence between ECs and SMCs, especially in highly rough regions. The profound role of surface topography overcoming the biochemical cue of released Mg
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.