Evidence map›Paper›PMID 32913920›Full record

ArticleAmerican journal of ophthalmology case reports2020

Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report.

Miguel Rechichi, Marco Ferrise, Francesco Romano, Luca Gallelli, Vincenzo Toschi, Andrea Dominijanni, Alessandro Meduri

Open access · goldAbstract readCase Reports
In one paragraph

Article in American journal of ophthalmology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Safety and efficacy of eye drops from umbilical cord blood platelet lysate to treat resistant corneal ulcer.Medical hypothesis, discovery & innovation ophthalmology journal · 2022
    Article
  9. Article
  10. Human Platelets Take up Anti-VEGF Agents.Journal of ophthalmology · 2021
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Miguel RechichiCentro Polispecialistico Mediterraneo, Sellia Marina, Catanzaro, Italy.
Marco FerriseBiomorf, University of Messina, Messina, 98100, Italy.
Francesco RomanoDepartment of General Medicine, ASP, Catanzaro, Italy.
Luca GallelliClinical Pharmacology and Pharmacovigilance Operative Unit, Mater Domini Hospital, Catanzaro, Italy.
Vincenzo ToschiDivision of Haematology and Blood Transfusion and Thrombosis Centre, AO Ospedale San Carlo Borromeo, Milan, Italy.
Andrea DominijanniAzienda Ospedaiera Pugliese Ciaccio, Catanzaro, Italy.
Alessandro MeduriCentro Polispecialistico Mediterraneo, Sellia Marina, Catanzaro, Italy.
Centro Polispecialistico MediterraneoAzienda Ospedaliera Pugliese Ciaccio · ITAzienda Ospedaliero Universitario Mater Domini · ITOspedale San Carlo · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the efficacy of a low-cost preparation of platelet-rich plasma (PRP) eye drops in the treatment of persistent non-infectious corneal ulcer. OBSERVATIONS: A 67-year-old female presented to our clinic with a wide corneal ulcer and severe paracentral corneal thinning refractory to medical therapy with antibiotics, lubricant and contact lens bandage. The patient received a novel preparation of PRP solution. After 15 days of therapy, we observed complete resolution of the corneal ulcer with regrowth of the epithelium and a reduction in corneal opacity. CONCLUSION AND IMPORTANCE: Although the low-cost PRP preparation gives a lower platelet concentration than standard procedures, our work shows this preparation to be effective in the treatment of refractory non-infectious corneal ulcer.

Indexed as

Corneal ulcerPlatelet-rich plasmaRefractory ulcer

Identifiers

PMID32913920
PMCPMC7472805
OpenAlexW3080364871

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.